Three-year outcomes of transcatheter aortic valve implantation for bicuspid versus tricuspid aortic stenosis

被引：29

作者：

Zhou, Dao ^{[1
]}

Yidilisi, Abuduwufuer ^{[1
]}

Fan, Jiaqi ^{[1
]}

Zhang, Yebei ^{[1
,2
]}

Dai, Hanyi ^{[1
]}

Zhu, Gangjie ^{[1
]}

Guo, Yuchao ^{[1
]}

He, Yuxin ^{[1
]}

Zhu, Qifeng ^{[1
]}

Lin, Xinping ^{[1
]}

Li, Huajun ^{[1
]}

Jiang, Jubo ^{[1
]}

Ng, Stella ^{[1
]}

Li, Cheng ^{[1
]}

Ren, Kaida ^{[1
]}

Wang, Lihan ^{[1
]}

Liu, Xianbao ^{[1
]}

Wang, Jian'an ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Ved, Affiliated Hosp 2, Dept Cardiol, Jiefang Rd 88, Hangzhou 310009, Peoples R China

[2] Peoples Hosp Anji, Dept Cardiol, Anji Cty, Zhejiang, Peoples R China

来源：

EUROINTERVENTION | 2022年 / 18卷 / 03期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

bicuspid aortic valve; haemodynamics; long-term outcomes; reverse modelling; transcatheter aortic valve implantation; REPLACEMENT; SOCIETY; IMPACT; REGURGITATION; ASSOCIATION;

D O I：

10.4244/EIJ-D-21-00734

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Transcatheter aortic valve implantation (TAVI) might be a feasible treatment option for more patients with bicuspid aortic valve (BAV) stenosis. However, long-term follow-up data in this population are scarce. Aims: The aim of this study was to evaluate three-year outcomes after TAVI in patients with BAV. Methods: A total of 246 consecutive patients who underwent TAVI at a single centre in China between March 2013 and February 2018 were enrolled in this study. Clinical outcomes, health status and echocardiography were followed and recorded for three years. Results: Among 109 (44.3%) BAV patients, 61.5% were Type 0 and 36.7% were Type 1 BAV patients. BAV patients were younger (75 vs 77 years, p=0.041) and had a lower Society of Thoracic Surgeons (STS) score (5.09 vs 6.00, p=0.026) compared to tricuspid aortic valve (TAV) patients. There were no differences in three-year survival rates between bicuspid and tricuspid patients (87.1% vs 79.5%, log-rank p=0.126). Multivariate Cox regression analysis adjusting for confounding factors revealed a similar risk of all-cause mortality in the BAV population (hazard ratio [HR] 0.86, 95% confidence interval [CI]: 0.44-1.70, p=0.666). Except for the rate of permanent pacemaker implantation that was lower in BAV patients (11.9% vs 21.9%, p=0.041), the incidence of other clinical adverse events was comparable between the two groups. Both BAV and TAV patients showed an obvious improvement in valve haemodynamics, which was sustained for three years. In addition, similar left ventricular reverse remodelling was found during follow-up. Conclusions: BAV patients showed similar satisfactory three-year clinical outcomes, persistent valve haemodynamics improvement, and obvious cardiac reverse remodelling after TAVI compared to TAV patients.

引用

页码：193 / +

页数：20

共 30 条

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