Synthesis and antimicrobial activity evaluation of new 1,2,4-triazoles and 1,3,4-thiadiazoles bearing imidazo[2,1-b]thiazole moiety

被引：200

作者：

Guzeldemirci, Nuray Ulusoy ^{[1
]}

Kucukbasmaci, Oemer ^{[2
]}

机构：

[1] Istanbul Univ, Fac Pharm, Dept Pharmaceut Chem, Istanbul, Turkey

[2] Istanbul Univ, Cerrahpasa Fac Med, Dept Microbiol, Istanbul, Turkey

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 01期

关键词：

Imidazo[2,1-b]thiazole; 1,2,4-Triazole; 1,3,4-Thiadiazole; Antibacterial activity; Antifungal activity; Antimycobacterial activity; ANTIINFLAMMATORY ACTIVITIES; ANTIMYCOBACTERIAL ACTIVITY; CYTOTOXICITY EVALUATION; ANTICONVULSANT ACTIVITY; ANTIFUNGAL ACTIVITY; ANTICANCER ACTIVITY; ANALGESIC ACTIVITY; ACID-DERIVATIVES; ANTIBACTERIAL; TUBERCULOSIS;

D O I：

10.1016/j.ejmech.2009.09.024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 4-alkyl/aryl-2,4-dihydro-5-((6-(4-bromophenyl)imidazo[2,1-b]thiazol-3-yl)methyl)-3H-1,2,4-triazole-3-thiones (3a-i) and 2-alkyl/arylamino-5-((6-(4-bromophenyl)imidazo[2,1-b]thiazol-3-yl) methyl)-1,3,4-thiadiazoles (4a-c) were synthesized starting from 6-(4-bromophenyl)imidazo [2,1-b]thiazole-3-acetic acid hydrazide. The newly synthesized compounds were characterized by IR, (1)H NMR, mass and elemental analysis. All compounds were tested for antibacterial and antifungal activities. The antimicrobial activities of the compounds were assessed by the microbroth dilution technique. The compounds were also evaluated for antituberculosis activity against Mycobacterium tuberculosis H(37)Rv (ATCC 27294). The preliminary results revealed that some of the compounds exhibited promising antimicrobial activities. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：63 / 68

页数：6

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