D-Galactose-induced accelerated aging model: an overview

被引：390

作者：

Azman, Khairunnuur Fairuz ^{[1
]}

Zakaria, Rahimah ^{[1
]}

机构：

[1] Univ Sains Malaysia, Sch Med Sci, Dept Physiol, Kota Baharu 16150, Kelantan, Malaysia

来源：

BIOGERONTOLOGY | 2019年 / 20卷 / 06期

关键词：

D-Galactose; Aging model; Senescence; Anti-aging; INDUCED OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; INFLAMMATORY RESPONSE; INNER-EAR; COGNITIVE IMPAIRMENT; INDUCED SENESCENCE; REDOX HOMEOSTASIS; MEMORY IMPAIRMENT; AUDITORY-CORTEX; GINSENOSIDE RG1;

D O I：

10.1007/s10522-019-09837-y

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

To facilitate the process of aging healthily and prevent age-related health problems, efforts to properly understand aging mechanisms and develop effective and affordable anti-aging interventions are deemed necessary. Systemic administration of D-galactose has been established to artificially induce senescence in vitro and in vivo as well as for anti-aging therapeutic interventions studies. The aim of this article is to comprehensively discuss the use of D-galactose to generate a model of accelerated aging and its possible underlying mechanisms involved in different tissues/organs.

引用

页码：763 / 782

页数：20

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