D-Galactose-induced accelerated aging model: an overview

被引:390
作者
Azman, Khairunnuur Fairuz [1 ]
Zakaria, Rahimah [1 ]
机构
[1] Univ Sains Malaysia, Sch Med Sci, Dept Physiol, Kota Baharu 16150, Kelantan, Malaysia
关键词
D-Galactose; Aging model; Senescence; Anti-aging; INDUCED OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; INFLAMMATORY RESPONSE; INNER-EAR; COGNITIVE IMPAIRMENT; INDUCED SENESCENCE; REDOX HOMEOSTASIS; MEMORY IMPAIRMENT; AUDITORY-CORTEX; GINSENOSIDE RG1;
D O I
10.1007/s10522-019-09837-y
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
To facilitate the process of aging healthily and prevent age-related health problems, efforts to properly understand aging mechanisms and develop effective and affordable anti-aging interventions are deemed necessary. Systemic administration of D-galactose has been established to artificially induce senescence in vitro and in vivo as well as for anti-aging therapeutic interventions studies. The aim of this article is to comprehensively discuss the use of D-galactose to generate a model of accelerated aging and its possible underlying mechanisms involved in different tissues/organs.
引用
收藏
页码:763 / 782
页数:20
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