Overexpression of Ref-1 Inhibits Lead-induced Endothelial Cell Death via the Upregulation of Catalase

被引：8
作者：
Lee, Kwon Ho
Lee, Sang Ki
Kim, Hyo Shin
Cho, Eun Jung
Joo, Hee Kyoung
Lee, Eun Ji
Lee, Ji Young
Park, Myoung Soo
Chang, Seok Jong [3 ]
Cho, Chung-Hyun [2 ]
Park, Jin Bong
Jeon, Byeong Hwa [1 ,2 ]
机构：
[1] Chungnam Natl Univ, Infect Signaling Network Res Ctr, Dept Physiol, Sch Med, Taejon 301131, South Korea
[2] Chungnam Natl Univ, Res Inst Med Sci, Sch Med, Taejon 301131, South Korea
[3] Seonam Univ, Dept Physiol, Coll Med, Namwon 590711, South Korea
来源：
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | 2009年 / 13卷 / 06期
关键词：
Apurinic/apyrimidinic endonuclease1/redox factor-1 (Ref-1); Lead; Cell death; Endothelial cells; Catalase; ANTIOXIDANT ENZYME EXPRESSION; REDOX FACTOR-I; OXIDATIVE STRESS; TNF-ALPHA; INDUCED HYPERTENSION; APURINIC ENDONUCLEASE; HYDROGEN-PEROXIDE; APOPTOSIS; TOXICITY; GLUTATHIONE;
D O I：
10.4196/kjpp.2009.13.6.431
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The role of apurinic/apyrimidinic endonuclease1/redox factor-1 (Ref-1) on the lead (Pb)-induced cellular response was investigated in the cultured endothelial cells. Ph caused progressive cellular death in endothelial cells, which occurred in a concentration- and time-dependent manner. However, Ref-1 overexpression with AdRef-1 significantly inhibited Pb-induced cell death in the endothelial cells. Also the overexpression of Ref-1 significantly suppressed Pb-induced superoxide and hydrogen peroxide elevation in the endothelial cells. Ph exposure induced the downregulation of catalase, it was inhibited by the Ref-1 overexpression in the endothelial cells. Taken together, our data suggests that the overexpression of Ref-1 inhibited Pb-induced cell death via the upregulation of catalase in the cultured endothelial cells.
引用
收藏
页码：431 / 436
页数：6
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