Evaluating dipolar source localization feasibility from intracerebral SEEG recordings

Stereo-electroencephalography (SEEG) is considered as the golden standard for exploring targeted structure' during pre-surgical evaluation in drug-resistant partial epilepsy. The depth electrodes, inserted in the brain consist of several collinear measuring contacts (sensors). Clinical routine analysis of SEEG signals is performe on bipolar montage, providing a focal view of the explored structures, thus eliminating activities of distan sources that propagate through the brain volume. We propose in this paper to exploit the common referenc, _SEEG signals. In this case, the volume propagation information is preserved and electrical source localization (ESL) approaches can be proposed. Current ESL approaches used to localize and estimate the activity of the neurz generators are mainly based on surface EEG/MEG signals, but very few studies exist on real SEEG recordings, an the case of equivalent current dipole source localization has not been explored yet in this context. In this study we investigate the influence of volume conduction model, spatial configuration of SEEG sensors and level of nois, on the ESL accuracy, using a realistic simulation setup. Localizations on real SEEG signals recorded durini intracerebral electrical stimulations (ICS, known sources) as well as on epileptic interictal spikes are carrie out. Our results show that, under certain conditions, a straightforward approach based on an equivalent curredipole model for the source and on simple analytical volume conduction models yields sufficiently precis. solutions (below 10 mm) of the localization problem. Thus, electrical source imaging using SEEG signals is promising tool for distant brain source investigation and might be used as a complement to routine visui interpretations. (C) 2014 Elsevier Inc. All rights reserve'