High Performance Liquid Chromatographic (HPLC) Method for the Estimation of Pitavastatin in Pharmaceuticals

被引：0

作者：

Abbas, Ghulam ^{[1
]}

Shah, Shahid ^{[2
]}

Shehzad, Muhammad Ahmed ^{[3
]}

Mallhi, Tauqeer Hussain ^{[4
]}

Khan, Yusra Habib ^{[4
]}

Iqbal, Azhar ^{[5
,6
]}

Ahmed, Muhammad Masood ^{[7
]}

Khan, Sajid Mehmood ^{[8
]}

Gulshan, Saima ^{[1
]}

Shahid, Syeda Maryam ^{[1
]}

Javed, Sadaf ^{[1
]}

机构：

[1] Govt Coll Univ Faisalabad, Fac Pharmaceut Sci, Dept Pharmaceut, Faisalabad, Pakistan

[2] Govt Coll Univ Faisalabad, Fac Pharmaceut Sci, Dept Pharm Practice, Faisalabad, Pakistan

[3] Bahauddin Zakariya Univ Multan, Dept Stat, Multan, Pakistan

[4] Jouf Univ, Coll Pharm, Dept Clin Pharm, Sakaka 72341, Al Jouf Provinc, Saudi Arabia

[5] Jouf Univ, Dept Operat Dent & Endodont, Coll Dent, Sakaka 72341, Al Jouf Provinc, Saudi Arabia

[6] Frontier Med & Dent Coll, Dept Operat Dent & Endodont, Abbottabad, Pakistan

[7] Bahauddin Zakariya Univ Multan, Fac Pharm, Multan, Pakistan

[8] Islamia Univ Bahawalpur, Fac Pharm & Alternat Medicines, Bahawalpur, Pakistan

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2022年 / 41卷 / 05期

关键词：

HPLC; pharmaceuticals; pitavastatin; SNEDDS; CALCIUM; VALIDATION;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An HPLC method was developed for the monitoring of pitavastatin in pharmaceuticals using C-18 column with detection wavelength at 278 nm. Phosphate buffer, acetonitrile and methanol with the ratio of 30:40:60 was selected as best mobile phase with pH 7.4 and pitavastatin was detected at 278 nm with flow rate of 1 mL/min. The retention time was 3.728 minute while the linearity was determined in the range of 300 to 800 ng/mL with 0.9997 coefficient of correlation. Percentage recoveries in terms of accuracy were in the range of 91.83 to 97.66%. Assay result of pitavastatin in self nanoemulsifying drug delivery system (SNEDDS) was 97.35 %. Method was successfully applied for determination of pitavastatin in developed SNEDDS due to its highest validity.

引用

页码：962 / 966

页数：5

共 12 条

[1]

Attari Z, 2016, LAT AM J PHARM, V35, P967

[2] Determination and quantification of pitavastatin calcium in tablet dosage formulation by HPTLC method [J].