Murine Peyer's patch dendritic cells prime naive CD4+ T cells to produce interferon-γ

被引：2

作者：

Sato, A ^{[1
]}

Hashiguchi, M ^{[1
]}

Hachimura, S ^{[1
]}

Kaminogawa, S ^{[1
]}

机构：

[1] Univ Tokyo, Dept Appl Biol Chem, Bunkyo Ku, Tokyo, Japan

来源：

CYTOTECHNOLOGY | 2002年 / 40卷 / 1-3期

关键词：

dendritic cells; IFN-gamma; IL-12; mucosal immunity; Peyer's patch;

D O I：

10.1023/A:1023949620172

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We investigated the role of Peyer's patch (PP) dendritic cells (DCs) in the production of interferon (IFN)-gamma from naive CD4(+) T cells of T cell receptor transgenic mice. PP DCs were found to prime naive CD4(+) T cells for the production of higher levels of IFN-gamma, when compared to spleen (SP) DCs. However, a similar level of interleukin-12 (IL-12) production was observed for PP and SP DCs stimulated via the CD40 molecule. In addition, PP DCs expressed slightly higher levels of B7.2 (CD86) compared to SP DCs. This data demonstrates that PP DCs have a distinct function in the induction of IFN-gammas and suggests that PP DCs may enhance IFN-gamma production via another cytokine or costimulatory molecule, in addition to IL-12.

引用

页码：31 / 38

页数：8

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