Palladium-Catalyzed N-Arylation of Sulfoximines with Aryl Sulfonates

被引：32

作者：

Yang, Qingjing ^{[1
]}

Choy, Pui Ying ^{[2
]}

Zhao, Qingyang ^{[2
]}

Leung, Man Pan ^{[2
]}

Chan, Hoi Shan ^{[2
]}

So, Chau Ming ^{[1
]}

Wong, Wing-Tak ^{[1
]}

Kwong, Fuk Yee ^{[1
,2
]}

机构：

[1] Hong Kong Polytech Univ, Shenzhen Res Inst SZRI, Shenzhen 518057, Peoples R China

[2] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 18期

基金：

中国国家自然科学基金;

关键词：

MEDICINAL CHEMISTRY; BOND ACTIVATION; ONE-POT; MESYLATES; LIGANDS; IODIDES; AMINATION; CHLORIDES; BROMIDES; TOSYLATES;

D O I：

10.1021/acs.joc.8b01599

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Palladium-catalyzed C-N bond coupling reaction between NH-sulfoximines and aryl halides (e.g., -Br, -I, and -CI and pseudohalides -OTf and -ONf) was successfully achieved. Nevertheless, aryl tosylates/mesylates left much to be achieved. In this report, a general N-arylation of sulfoximines with aryl sulfonates is described. Using Pd(OAc)(2)/MeO-CM-phos complex, the N-aryl sulfoximine products can be obtained in good-to-excellent yields (up to 99%) with good common functional group compatibility. In addition to arene moieties, alkenyl tosylates are shown to be successful coupling partners.

引用

页码：11369 / 11376

页数：8

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