Managing diabetes in diabetic patients with COVID: where do we start from?

被引：9

作者：

Avogaro, Angelo ^{[1
]}

Bonora, Benedetta ^{[1
]}

Fadini, Gian Paolo ^{[1
]}

机构：

[1] Univ Padua, Dept Med, Unit Metab Dis, Via Giustiniani 2, I-35128 Padua, Italy

来源：

ACTA DIABETOLOGICA | 2021年 / 58卷 / 11期

关键词：

SARS-CoV-2; COVID-19; Diabetes mellitus; Type; 2; Metformin; Diabetes treatment; PEPTIDE-1; ANALOG; L CELLS; METFORMIN; ASSOCIATION; INHIBITORS; MORTALITY; ADMISSION; MELLITUS; OUTCOMES; DISEASE;

D O I：

10.1007/s00592-021-01739-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims COVID-19 has and still is sweeping away the national health systems worldwide. In this review, we sought to determine the evidence base proofs on the antidiabetic treatment capable to reduce the risk of COVID-19-related mortality. Methods We have performed a systematic search of published articles using PubMed, and EMBASE from March 2020 to March 31st, 2021. We excluded editorials, commentary, letters to the editor, reviews, and studies that did not have mortality as an outcome. For metformin and insulin only, we performed a meta-analysis using Cochrane RevMan 5.2. Results Among antidiabetic drugs, metformin was the only drug associated with a reduced risk of mortality. Conversely, insulin appears associated with an increased risk. The other classes of drugs were neutral. Conclusions The totality of articles reports retrospective data strongly affected by "channeling bias" so that most of the existing results on each class of drugs are driven by the phenotype of patients likely to receive that specific drug by prescription.

引用

页码：1441 / 1450

页数：10

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