The effect of kiwifruit consumption on blood pressure in subjects with moderately elevated blood pressure: A randomized, controlled study

被引:19
作者
Svendsen, Mette [1 ]
Tonstad, Serena [1 ]
Heggen, Eli [1 ]
Pedersen, Terje R. [1 ,2 ]
Seljeflot, Ingebjorg [2 ,3 ]
Bohn, Siv K. [4 ]
Bastani, Nasser E. [4 ]
Blomhoff, Rune [4 ]
Holme, Ingar M. [5 ]
Klemsdal, Tor O. [1 ]
机构
[1] Oslo Univ Hosp, Div Endocrinol Obes & Prevent Med, Sect Prevent Cardiol, N-0424 Oslo, Norway
[2] Univ Oslo, Fac Med, Oslo, Norway
[3] Oslo Univ Hosp, Dept Cardiol, Ctr Clin Heart Res, Ulleval, Norway
[4] Univ Oslo, Inst Nutr Res, Oslo, Norway
[5] Oslo Univ Hosp, Dept Biostat Epidemiol & Hlth Econ, N-0424 Oslo, Norway
关键词
Ambulatory blood pressure; endothelial function; NO formation; PLASMA CAROTENOIDS; OXIDATIVE STRESS; CLINICAL-TRIAL; FRUIT; VEGETABLES; SUPPLEMENTATION; ANTIOXIDANTS; RISK; FOOD;
D O I
10.3109/08037051.2014.976979
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Background and aims. Kiwifruit contains bioactive substances that may lower blood pressure (BP) and improve endothelial function. We examined the effects of adding kiwifruit to the usual diet on 24-h ambulatory BP, office BP and endothelial function. Methods. In a parallel-groups study, 118 subjects with high normal BP or stage 1 hypertension (systolic BP 130-159 mmHg and/or diastolic BP 85-99 mmHg) were randomized to intake of three kiwifruits (intervention) or one apple (control) a day for 8 weeks. Office and 24-h ambulatory BP was measured along with biomarkers of endothelial function including metabolites of nitric oxide (NO) formation and finger photo-plethysmography. Results. At randomization, mean 24-h ambulatory systolic/diastolic BP was 133 +/- 13/82 +/- 9 mmHg (n = 106). After 8 weeks, BP was lower in the group assigned to kiwifruit versus apple intake (between group difference, - 3.6 mmHg [95% CI - 6.5 to - 0.7], p = 0.017 and - 1.9 mmHg [95% CI - 3.6 to - 0.3]; p = 0.040, for systolic and diastolic BP, respectively). Changes in office BP and endothelial function did not differ between the groups. Conclusions. Among men and women with moderately elevated BP, intake of three kiwifruits was associated with lower systolic and diastolic 24-h BP compared with one apple a day. The effect may be regulated by mechanisms other than improvement of endothelial function.
引用
收藏
页码:48 / 54
页数:7
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