[1] Univ Lisbon, Inst Invest Medicamento iMed ULisboa, Fac Farm, Lisbon, Portugal
[2] Univ Lisbon, Inst Med Mol Joao Lobo Antunes, Fac Med, Lisbon, Portugal
[3] Univ Lisbon, Inst Farmacol & Neurociencias, Fac Med, Lisbon, Portugal
[4] Univ Lisbon, Dept Ciencias Farmaceut & Medicamento, Fac Farm, Lisbon, Portugal