Electro-mechanical coupling in a one-dimensional model of heart muscle fiber

被引：7

作者：

Katsnelson, Leonid B. ^{[1
]}

Vikulova, Natalia A. ^{[1
]}

Kursanov, Alexander G. ^{[1
]}

Solovyova, Olga E. ^{[1
]}

Markhasin, Vladimir S. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Immunol & Physiol, Ural Branch, Ekaterinburg 620219, Russia

来源：

RUSSIAN JOURNAL OF NUMERICAL ANALYSIS AND MATHEMATICAL MODELLING | 2014年 / 29卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

Cardiac mechano-electric feedback; heterogeneous myocardium; mathematical modelling; CARDIAC-MUSCLE; ELECTROPHYSIOLOGY;

D O I：

10.1515/rnam-2014-0022

中图分类号：

O29 [应用数学];

学科分类号：

070104 ;

摘要：

We developed a mathematical model that describes heart muscle fiber as a one-dimensional continuous medium of electrically and mechanically coupled cardiomyocytes through which electrical excitation propagates and initiates muscle contraction. The generic model simulates bilateral relations between the electrical and the mechanical activity of cardiomyocytes in the tissue and accounts for both intracellular and intercellular electro-mechanical couplings and mechano-electric feedback mechanisms.

引用

页码：275 / 284

页数：10

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