Urea-Induced Drying of Carbon Nanotubes Suggests Existence of a Dry Globule-like Transient State During Chemical Denaturation of Proteins

被引：57

作者：

Das, Payel ^{[1
]}

Zhou, Ruhong ^{[1
]}

机构：

[1] IBM Corp, Thomas J Watson Res Ctr, Computat Biol Ctr, Yorktown Hts, NY 10598 USA

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2010年 / 114卷 / 16期

关键词：

DISPERSION INTERACTIONS; HYDROPHOBIC COLLAPSE; WATER; GUANIDINIUM; TRANSPORT; MECHANISM; CHANNEL; MODEL;

D O I：

10.1021/jp911444q

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Atomistic dynamics simulations of purely hydrophobic carbon nanotubes in 8 M urea are performed to dissect the role of dispersion interactions in the denaturing power of urea. The enhanced population of urea and a paucity of water in proximity of nanotubes suggest that the stronger dispersion interaction of urea than water with nanotube triggers drying of its interior. The preferential intrusion of urea over water within nanotube interiors irrespective of their diameters directly implies a "dry globule"-like transient intermediate formation in the initial stage of protein unfolding in urea.

引用

页码：5427 / 5430

页数：4

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