Myeloid-Derived Suppressor Cells as a Regulator of Immunity in Organ Transplantation

被引:38
作者
Nakamura, Tsukasa [1 ]
Ushigome, Hidetaka [1 ]
机构
[1] Kyoto Prefectural Univ Med, Dept Organ Transplantat & Gen Surg, Kyoto 6028566, Japan
关键词
myeloid-derived suppressor cells; organ transplantation; tolerance; regulatory T cells; regulatory B cells; iNKT cells; regulatory dendritic cells; regulatory macrophages; CARDIAC ALLOGRAFT SURVIVAL; ARYL-HYDROCARBON RECEPTOR; COLONY-STIMULATING FACTOR; HEPATIC STELLATE CELLS; T-CELLS; DENDRITIC CELLS; NITRIC-OXIDE; B-CELLS; RENAL-TRANSPLANTATION; MOUSE MODEL;
D O I
10.3390/ijms19082357
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Regulation of allo-immune responses is proposed as a topic for investigation in the current field of organ transplantation. As a regulator, regulatory T cells (Tregs) have received attention due to their ability to control allograft rejection. Concurrently, however, the independent action of Tregs is not enough to achieve tolerance status in many situations. Meanwhile, as a multi-functional regulator, myeloid-derived suppressor cells (MDSCs) can suppress effector T cells as well as induce Tregs or regulatory B cells (Bregs) in certain circumstances. Furthermore, the importance of a crosstalk between MDSCs and natural killer T cells to induce tolerance has been reported. Thus, orchestration between MDSCs, myeloid regulators, T/Bregs and other lymphoid/myeloid regulators can shed light on achieving allogeneic tolerance. Here, we review the current knowledge in terms of immunological regulatory function displayed by MDSCs in the context of organ transplantation. Ideal control of MDSCs would lead to a reduction of allograft rejection and subsequent long-term allograft acceptance.
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页数:22
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