A Practical Synthesis of Regioisomeric 6-and 7-Methoxytetrahydro-3-benzazepines

被引：6

作者：

Liang, Jimmy T. ^{[1
]}

Liu, Jing ^{[1
]}

Shireman, Brock T. ^{[1
]}

Tran, Vi ^{[1
]}

Deng, Xiaohu ^{[1
]}

Mani, Neelakandha S. ^{[1
]}

机构：

[1] Johnson & Johnson Pharmaceut Res & Dev LLC, San Diego, CA 92121 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2010年 / 14卷 / 02期

关键词：

DOPAMINE D-1 ANTAGONIST; FUSED BENZAZEPINE; STEREOSELECTIVE SYNTHESES; BIOLOGICAL EVALUATION; RECEPTOR ANTAGONISTS; SCH; 39166; POTENT; SERIES;

D O I：

10.1021/op900292j

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A concise and versatile synthetic route for 6- and 7-methoxy tetrahydro-3-benzazepines is described. The key feature of the synthesis is a one-pot acylatioti/cyclizaition/elimination sequence to construct either of the isomeric dihydrobenzazepine ring systems from the same starting material. The route is high yielding and chromatography-free.

引用

页码：380 / 385

页数：6

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