PI3K/Akt Pathway: A Potential Therapeutic Target for Chronic Pain

被引：97

作者：

Chen, Shu-Ping ^{[1
,2
]}

Zhou, Ya-Qun ^{[1
,2
]}

Liu, Dai-Qiang ^{[1
,2
]}

Zhang, Wen ^{[1
,2
]}

Manyande, Anne ^{[3
]}

Guan, Xue-Hai ^{[1
,2
]}

Tian, Yu-Ke ^{[1
,2
]}

Ye, Da-Wei ^{[4
]}

Omar, Deeq Mohamed ^{[5
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Anesthesiol Inst, Wuhan, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Anesthesiol & Pain Med, Wuhan, Peoples R China

[3] Univ West London, Sch Psychol Social Work & Human Sci, Brentford, England

[4] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Canc Ctr, Wuhan, Peoples R China

[5] Huazhong Univ Sci & Technol, Tongji Med Coll, MBBS, Wuhan, Peoples R China

来源：

CURRENT PHARMACEUTICAL DESIGN | 2017年 / 23卷 / 12期

关键词：

PI3K; Akt; chronic pain; bone cancer pain; neuropathic pain; inflammatory pain; opioid tolerance; SPINAL-CORD-INJURY; BONE CANCER PAIN; NERVE GROWTH-FACTOR; PROTEIN-KINASE B/AKT; NF-KAPPA-B; DORSAL-ROOT GANGLIA; PHOSPHATIDYLINOSITOL; 3-KINASE; NEUROPATHIC PAIN; SENSORY NEURONS; CENTRAL SENSITIZATION;

D O I：

10.2174/1381612823666170210150147

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chronic pain is among the most disabling and costly disorders, with prevalence ranging from 10% to 55%. However, current therapeutic strategies for chronic pain are unsatisfactory due to our poor understanding of its mechanisms. Thus, novel therapeutic targets need to be found in order to improve these patients' quality of life. PI3K and its downstream Akt are widely expressed in the spinal cord, particularly in the laminae I-IV of the dorsal horn, where nociceptive C and A delta fibers of primary afferents principally terminate. Recent studies have demonstrated their critical roles in the development and maintenance of chronic pain. In this review, we summarized the roles and mechanisms of PI3K/Akt pathway in the progression of chronic pain through sciatic nerve injury, diabetic neuropathy, spinal cord injury, bone cancer, opioid tolerance, or opioid-induced hyperalgesia.

引用

页码：1860 / 1868

页数：9

共 135 条

[1] Diabetic Neuropathy: Mechanisms, Emerging Treatments, and Subtypes [J].