Phase Ib study of binimetinib (MEK162) in combination with capecitabine in gemcitabine-pretreated advanced biliary tract cancer.

被引:1
|
作者
Kim, Jin Won
Lee, Kyung-Hun
Kim, Ji-Won
Suh, Koung Jin
Bang, Ju-Hee
Bang, Yung-Jue
Oh, Do-Youn
机构
[1] Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Internal Med, Seongnam, South Korea
[2] Seoul Natl Univ Hosp, Seoul, South Korea
[3] Seoul Natl Univ, Coll Med, Canc Res Inst, Seoul, South Korea
[4] Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Seoul, South Korea
[5] Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Dept Internal Med, Seoul, South Korea
关键词
D O I
10.1200/JCO.2018.36.15_suppl.4079
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
4079
引用
收藏
页数:1
相关论文
共 50 条
  • [1] A phase Ib/II study of MEK162 (binimetinib [BINI]) in combination with imatinib in patients with advanced gastrointestinal stromal tumor (GIST)
    Chi, Ping
    Qin, Li-Xuan
    D'Angelo, Sandra P.
    Dickson, Mark Andrew
    Gounder, Mrinal M.
    Keohan, Mary Louise
    Shoushtari, Alexander Noor
    Condy, Mercedes M.
    Konen, Theresa
    Fruauff, Alana
    DeMatteo, Ronald P.
    Singer, Samuel
    Hwang, Sinchun
    Antonescu, Cristina R.
    Tap, William D.
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
  • [2] A phase I study of MEK inhibitor MEK162 (ARRY-438162) in patients with biliary tract cancer.
    Finn, Richard S.
    Javle, Milind M.
    Tan, Benjamin R.
    Weekes, Colin D.
    Bendell, Johanna C.
    Patnaik, Amita
    Khan, Gazala Naaz
    Laheru, Dan
    Anderson, Lisa
    Christy-Bittel, Janna Lynn
    Barrett, Emma
    Guthrie, Kari
    Litwiler, Kevin S.
    Bekaii-Saab, Tanios S.
    JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (04)
  • [3] A phase I study of binimetinib (MEK162) in Japanese patients with advanced solid tumors
    Watanabe, K.
    Otsu, S.
    Hirashima, Y.
    Morinaga, R.
    Nishikawa, K.
    Hisamatsu, Y.
    Shimokata, T.
    Inada-Inoue, M.
    Shibata, T.
    Takeuchi, H.
    Watanabe, T.
    Tokushige, K.
    Maacke, H.
    Shiaro, K.
    Ando, Y.
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2016, 77 (06) : 1157 - 1164
  • [4] A phase I study of binimetinib (MEK162) in Japanese patients with advanced solid tumors
    K. Watanabe
    S. Otsu
    Y. Hirashima
    R. Morinaga
    K. Nishikawa
    Y. Hisamatsu
    T. Shimokata
    M. Inada-Inoue
    T. Shibata
    H. Takeuchi
    T. Watanabe
    K. Tokushige
    H. Maacke
    K. Shiaro
    Y. Ando
    Cancer Chemotherapy and Pharmacology, 2016, 77 : 1157 - 1164
  • [5] Phase Ib study of gemcitabine and oxaliplatin with erlotinib in patients with advanced biliary tract cancer.
    Ciombor, Kristen Keon
    Cardin, Dana Backlund
    Chan, Emily
    McClanahan, Pamela
    Fan, Kang-Hsien
    Flynn, Jayme
    Young, Ruth T.
    DeMers, April
    Smith, Stephen James
    Berlin, Jordan
    Goff, Laura Williams
    JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (15)
  • [6] Enhanced antitumor effect of binimetinib in combination with capecitabine for biliary tract cancer patients with mutations in the RAS/RAF/MEK/ERK pathway: phase Ib study
    Jin Won Kim
    Kyung-Hun Lee
    Ji-Won Kim
    Koung Jin Suh
    Ah-Rong Nam
    Ju-Hee Bang
    Yung-Jue Bang
    Do-Youn Oh
    British Journal of Cancer, 2019, 121 : 332 - 339
  • [7] Enhanced antitumor effect of binimetinib in combination with capecitabine for biliary tract cancer patients with mutations in the RAS/RAF/MEK/ERK pathway: phase Ib study
    Kim, Jin Won
    Lee, Kyung-Hun
    Kim, Ji-Won
    Suh, Koung Jin
    Nam, Ah-Rong
    Bang, Ju-Hee
    Bang, Yung-Jue
    Oh, Do-Youn
    BRITISH JOURNAL OF CANCER, 2019, 121 (04) : 332 - 339
  • [8] A Phase I/Ib study of MEK162 (binimetinib), a MEK inhibitor, in combination with carboplatin and pemetrexed in patients with non-squamous NSCLC.
    Karim, Safiya
    Feld, Ronald
    Leighl, Natasha B.
    Shepherd, Frances A.
    Bradbury, Penelope Ann
    Liu, Geoffrey
    Graham, Donna M.
    JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
  • [9] Oral capecitabine in gemcitabine-pretreated patients with advanced pancreatic cancer
    Boeck, Stefan
    Wilkowski, Ralf
    Bruns, Christiane J.
    Issels, Rolf D.
    Schulz, Christoph
    Moosmann, Nicolas
    Laessig, Dorit
    Haas, Michael
    Golf, Alexander
    Heinemann, Volker
    ONCOLOGY, 2007, 73 (3-4) : 221 - 227
  • [10] A Phase I/Ib Study of Binimetinib (MEK162), a MEK Inhibitor Plus Carboplatin/Pemetrexed in Non-Squamous NSCLC
    Graham, D.
    Chen, E.
    Pisters, K.
    Bradbury, P.
    Trinkaus, M.
    Chan, M.
    Arif, S.
    Zurawska, U.
    Rothenstein, J.
    Zawisza, D.
    Effendie, S.
    Sawczak, M.
    Leighl, N.
    JOURNAL OF THORACIC ONCOLOGY, 2018, 13 (10) : S481 - S482