Impedance Based Detection of Chemical Warfare Agent Mimics Using Ferrocene-Lysine Modified Carbon Nanotubes

被引：53
作者：
Diakowski, Piotr M. [1 ]
Xiao, Yizhi [1 ]
Petryk, Michael W. P. [2 ]
Kraatz, Heinz-Bernhard [1 ]
机构：
[1] Univ Western Ontario, Dept Chem, London, ON N6A 5B7, Canada
[2] DRDC Suffield, Medicine Hat, AB T1A 8K6, Canada
来源：
ANALYTICAL CHEMISTRY | 2010年 / 82卷 / 08期
基金：
加拿大自然科学与工程研究理事会;
关键词：
ELECTROCHEMICAL PROPERTIES; REDOX BEHAVIOR; ELECTRODE; SPECTROSCOPY; SURFACE; SENSOR; GOLD;
D O I：
10.1021/ac902694d
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A recognition layer formed by multiwalled carbon nanotubes (MWCNTs) covalently modified with a ferrocene-lysine conjugate deposited on the indium tin oxide (ITO) was investigated as a sensor for chemical warfare agent (CWA) mimics. Electrochemical impedance spectroscopy measurements showed that upon addition of CWA mimic dramatic changes occurred in the electrical properties of the recognition layer. These changes allowed the detection of nerve agent analogues at the micromolar level, and a limited sensitivity was observed toward a sulfur mustard mimic. Experimental parameters were optimized so as to allow the detection of CWAs at single frequency, thereby significantly reducing acquisition time and simplifying data treatment. A proposed method of detection represents a significant step toward the design of an affordable and "fieldable" electrochemical CWA sensor.
引用
收藏
页码：3191 / 3197
页数：7
相关论文
共 39 条
[1]  
[Anonymous], 2001, ELECTROCHEMICAL METH
[2]  
Barsoukov E, 2005, IMPEDANCE SPECTROSCOPY: THEORY, EXPERIMENT, AND APPLICATIONS, 2ND EDITION, pXII
[3]   THE ANALYSIS OF ELECTRODE IMPEDANCES COMPLICATED BY THE PRESENCE OF A CONSTANT PHASE ELEMENT [J].
BRUG, GJ ;
VANDENEEDEN, ALG ;
SLUYTERSREHBACH, M ;
SLUYTERS, JH .
JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 1984, 176 (1-2) :275-295
[4]   Microsynthesis and gas chromatography/electron ionization mass spectrometric and tandem mass spectrometric analysis of cyclic alkylphosphonates for verification of the Chemical Weapons Convention [J].
Dubey, Devendra K. ;
Pardasani, Deepak ;
Kanaujia, Pankaj K. ;
Tak, Vijay ;
Gupta, Hernendra K. .
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2008, 22 (16) :2526-2532
[5]   Relationships between basicity, redox behaviour of ferrocenylamines and their reactivity with Pt[II] compounds [J].
Duffy, NW ;
Harper, J ;
Ramani, P ;
Ranatunge-Bandarage, R ;
Robinson, BH ;
Simpson, J .
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1998, 564 (1-2) :125-131
[6]   Electrochemical impedance spectroscopy at single-walled carbon nanotube network ultramicroelectrodes [J].
Dumitrescu, Ioana ;
Unwin, Patrick R. ;
Macpherson, Julie V. .
ELECTROCHEMISTRY COMMUNICATIONS, 2009, 11 (11) :2081-2084
[7]   Mobile chemical detector (AP2C+SP4E) as an aid for medical decision making in the battlefield [J].
Eisenkraft, Arik ;
Markel, Gal ;
Simovich, Shirley ;
Layish, Ido ;
Hoffman, Azik ;
Finkelstein, Arseny ;
Rotman, Eran ;
Dushnitsky, Tsvika ;
Krivoy, Amir .
MILITARY MEDICINE, 2007, 172 (09) :997-1001
[8]   Nanostructuring electrodes with carbon nanotubes: A review on electrochemistry and applications for sensing [J].
Gooding, JJ .
ELECTROCHIMICA ACTA, 2005, 50 (15) :3049-3060
[9]   Protein electrochemistry using aligned carbon nanotube arrays [J].
Gooding, JJ ;
Wibowo, R ;
Liu, JQ ;
Yang, WR ;
Losic, D ;
Orbons, S ;
Mearns, FJ ;
Shapter, JG ;
Hibbert, DB .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (30) :9006-9007
[10]   Standoff detection of chemical and biological threats using laser-induced breakdown spectroscopy [J].
Gottfried, Jennifer L. ;
De Lucia, Frank C., Jr. ;
Munson, Chase A. ;
Miziolek, Andrzej W. .
APPLIED SPECTROSCOPY, 2008, 62 (04) :353-363
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