MicroRNA regulation of extracellular matrix components in the process of atherosclerotic plaque destabilization

被引：18
作者：
Kowara, Michal [1 ,2 ]
Cudnoch-Jedrzejewska, Agnieszka [1 ]
Opolski, Grzegorz [2 ]
Wlodarski, Pawel [3 ]
机构：
[1] Med Univ Warsaw, Dept Expt & Clin Physiol, Lab Ctr Preclin Res, Warsaw, Poland
[2] Med Univ Warsaw, Dept Cardiol 1, Warsaw, Poland
[3] Med Univ Warsaw, Dept Histol & Embryol, Ctr Biostruct Res, Lab Ctr Preclin Res, Warsaw, Poland
来源：
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2017年 / 44卷 / 07期
关键词：
atherosclerosis; collagen; extracellular matrix; metalloproteinases; RNA interference; MUSCLE-CELL MIGRATION; APOLIPOPROTEIN-E; VULNERABLE PLAQUE; CYSTATIN-C; CARDIOVASCULAR-DISEASE; COLLAGEN CONTENT; MAST-CELLS; EXPRESSION; PROGRESSION; PROTEOGLYCANS;
D O I：
10.1111/1440-1681.12772
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The process of atherosclerotic plaque destabilization, leading to myocardial infarction, is still not fully understood. The pathway - composed of structural and regulatory proteins of the extracellular matrix (ECM) such as collagen, elastin, small leucine-rich proteoglycans, metalloproteinases, cathepsins and serine proteases - is one potential way of atherosclerotic plaque destabilization. The expression of these proteins is controlled by different microRNA molecules. The goal of this paper is to summarize the current investigations and knowledge about ECM in the process of atherosclerotic plaque destabilization, giving special attention to epigenetic expression regulation by microRNA.
引用
收藏
页码：711 / 718
页数：8
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共 102 条
  • [1] Recent Advances on the Role of Cytokines in Atherosclerosis
    Ait-Oufella, Hafid
    Taleb, Soraya
    Mallat, Ziad
    Tedgui, Alain
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2011, 31 (05) : 969 - 979
  • [2] MicroRNA-27b Regulates the Expression of Matrix Metalloproteinase 13 in Human Osteoarthritis Chondrocytes
    Akhtar, Nahid
    Rasheed, Zafar
    Ramamurthy, Sangeetha
    Anbazhagan, Arivarasu N.
    Voss, Frank R.
    Haqqi, Tariq M.
    [J]. ARTHRITIS AND RHEUMATISM, 2010, 62 (05): : 1361 - 1371
  • [3] Human macrophage foam cells degrade atherosclerotic plaques through cathepsin K mediated processes
    Barascuk, Natasha
    Skjot-Arkil, Helene
    Register, Thomas C.
    Larsen, Lise
    Byrjalsen, Inger
    Christiansen, Claus
    Karsdal, Morten A.
    [J]. BMC CARDIOVASCULAR DISORDERS, 2010, 10
  • [4] Mechanisms of Plaque Formation and Rupture
    Bentzon, Jacob Fog
    Otsuka, Fumiyuki
    Virmani, Renu
    Falk, Erling
    [J]. CIRCULATION RESEARCH, 2014, 114 (12) : 1852 - 1866
  • [5] Mast Cells as Effectors in Atherosclerosis
    Bot, Ilze
    Shi, Guo-Ping
    Kovanen, Petri T.
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2015, 35 (02) : 265 - 271
  • [6] Mast cell chymase inhibition reduces atherosclerotic plaque progression and improves plaque stability in ApoE-/- mice
    Bot, Ilze
    Bot, Martine
    van Heiningen, Sandra H.
    van Santbrink, Peter J.
    Lankhuizen, Inge M.
    Hartman, Peter
    Gruener, Sabine
    Hilpert, Hans
    van Berkel, Theo J. C.
    Fingerle, Juergen
    Biessen, Erik A. L.
    [J]. CARDIOVASCULAR RESEARCH, 2011, 89 (01) : 244 - 252
  • [7] Hyaluronic acid metabolism is increased in unstable plaques
    Bot, Pieter T.
    Pasterkamp, Gerard
    Goumans, Marie-Jose
    Strijder, Chaylendra
    Moll, Frans L.
    de Vries, Jean-Paul
    Pals, Steven T.
    de Kleijn, Dominique P.
    Piek, Jan J.
    Hoefer, Imo E.
    [J]. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2010, 40 (09) : 818 - 827
  • [8] Up-regulation of Histone Methyltransferase, DOT1L, by Matrix Hyaluronan Promotes MicroRNA-10 Expression Leading to Tumor Cell Invasion and Chemoresistance in Cancer Stem Cells from Head and Neck Squamous Cell Carcinoma
    Bourguignon, Lilly Y. W.
    Wong, Gabriel
    Shiina, Marisa
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (20) : 10571 - 10585
  • [9] Loss of protease activity of ADAM15 abolishes protective effects on plaque progression in atherosclerosis
    Bueltmann, Andreas
    Li, Zhongmin
    Wagner, Silvia
    Gawaz, Meinrad
    Ungerer, Martin
    Langer, Harald
    May, Andreas E.
    Muench, Goetz
    [J]. INTERNATIONAL JOURNAL OF CARDIOLOGY, 2011, 152 (03) : 382 - 385
  • [10] Changing Views of the Biomechanics of Vulnerable Plaque Rupture: A Review
    Cardoso, Luis
    Weinbaum, Sheldon
    [J]. ANNALS OF BIOMEDICAL ENGINEERING, 2014, 42 (02) : 415 - 431
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