Interferon-γ-induced growth inhibition of neuroblastoma cells is independent of induction of nitric oxide synthase and indoleamine 2,3-dioxygenase

被引：0

作者：

Leitner, S ^{[1
]}

Golderer, G ^{[1
]}

Winkler, C ^{[1
]}

Fuchs, D ^{[1
]}

Werner-Felmayer, G ^{[1
]}

Werner, ER ^{[1
]}

机构：

[1] Univ Innsbruck, Inst Med Chem & Biochem, A-6020 Innsbruck, Austria

来源：

PTERIDINES | 2004年 / 15卷 / 03期

关键词：

neuroblastoma; nitric oxide synthase; indoleamine 2,3-dioxygenase; interferon-gamma; interleukin-1-beta;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated a possible involvement of nitric oxide formed by inducible nitric oxide synthase (iNOS) in the signaling cascade leading to growth inhibition and differentiation in the human neuroblastoma cell line SK-N-SH. Treatment of SK-N-SH with interferon-gamma (IFN-gamma) plus interleukin-1beta (IL-1beta) led to induction of iNOS, growth inhibition and an altered cell shape. However two inhibitors of iNOS were not able to prevent cytokine induced changes. In addition, IFN-gamma alone led to growth inhibition in absence of iNOS induction. Inhibition of the induced indoleamine 2,3-dioxygenase (IDO) activity also did not prevent growth inhibition. Our findings show that mechanisms other than NO and IDO can control interferon-gamma-induced growth inhibition of SK-N-SH cells.

引用

页码：91 / 96

页数：6

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