Elevated serum levels of interleukin-10 in adult-onset Still's disease are associated with disease activity

被引：24

作者：

Sun, Yue ^{[1
]}

Wang, Zhihong ^{[1
]}

Chi, Huihui ^{[1
]}

Hu, Qiongyi ^{[1
]}

Ye, Junna ^{[1
]}

Liu, Honglei ^{[1
]}

Cheng, Xiaobing ^{[1
]}

Shi, Hui ^{[1
]}

Zhou, Zhuochao ^{[1
]}

Teng, Jialin ^{[1
]}

Yang, Chengde ^{[1
]}

Su, Yutong ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Rheumatol & Immunol, Sch Med, 197 Ruijin Second Rd, Shanghai 200025, Peoples R China

来源：

CLINICAL RHEUMATOLOGY | 2019年 / 38卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Adult-onset Still's disease; Disease activity; IL-10; Inflammation; CYTOKINE PROFILES; IL-10; EXPRESSION; IL-37;

D O I：

10.1007/s10067-019-04642-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To evaluate the serum levels of the anti-inflammatory cytokine interleukin-10 (IL-10) in patients with adult-onset Still's disease (AOSD), a rare, systemic, and multigenic inflammatory disease. The serum levels of IL-10, IL-1 beta, IL-6, IL-18, and TNF-alpha were examined by electrochemiluminescence assay. The serum levels of IL-10 were higher in AOSD patients than in healthy controls and positively correlated with systemic score, erythrocyte sedimentation rate (ESR), C-reactive protein level (CRP), ferritin, and inflammatory cytokine (IL-1 beta, IL-6, IL-18, and TNF-alpha) levels. Moreover, the levels of IL-10 were significantly higher in AOSD patients who had fever, sore throat, rash, lymphadenopathy, splenomegaly, pneumonia, and arthralgia than in patients who did not. IL-10 was increased in AOSD patients and correlated with disease activity.

引用

页码：3205 / 3210

页数：6

共 24 条

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