Electrospun multifaceted nanocomposites for promoting angiogenesis in curing burn wound

Burn wound care always remains a herculean task owing to its myriad of complications following injury. The current work describes the development of a biodegradable 3D framework fabricated from PVA, gelatin, chitosan polymers embedded with ferulic acid and resveratrol with direct influence on cellular recruitment and activation, without altering the temporal sequence of the healing process. The structural analysis of the scaffold revealed randomly oriented highly interconnected porous structured fibers which favored cell adhesion, migration and proliferation. Furthermore, the physico-chemical characterisation elucidated good compatibility of the drugs with the scaffolds and in-vitro release profile exhibited the sustained release of bioactive components up to 96 h endorsing the fabricated nanofibrous scaffold as a controlled drug delivery system. The drug incorporated nanofibrous construct exhibited an extensive potential in augmenting angiogenesis and cell migration (82% wound closure at 8 h) in in-vitro studies. The biotherapeutic nanofibrous scaffold enhanced the restoration of wounded tissue in in-vivo models. Thus, the present study strides way for developing, biomimetic nanofibrous scaffolds with sequential drug delivery for chronic wound management.