Prenatal presentation supports the in utero development of congenital leukemia: A case report

被引:14
作者
Bayoumy, M
Wynn, T
Jamil, A
Kahwash, S
Klopfenstein, K
Ruymann, F
机构
[1] Columbus Childrens Hosp, Div Pediat Hematol Oncol, Hematol Oncol Sect, Columbus, OH 43205 USA
[2] Columbus Childrens Hosp, Sect Pathol, Columbus, OH 43205 USA
关键词
congenital leukemia; infant leukemia; neonatal cancer; acute monoblastic leukemia; karyotype;
D O I
10.1097/00043426-200302000-00013
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Congenital leukemia is a rare disease developing within the first 4 to 6 weeks of life. We report a female infant born with facial mass and multiple subcutaneous nodules. The facial mass was discovered by ultrasound during a routine prenatal examination at the 36th week of gestation. Biopsies were consistent with the diagnosis of acute monoblastic leukemia (AML, FAB M5b). Cytogenetic studies showed 46 XX, t(11;19)(q23;p13.1), which is only found in acute monoblastic leukemia and involve, the ELL gene. The infant died at 12 days of age and autopsy revealed a large leukemic tumor burden in several body organs. The discovery of the facial mass prenatally and massive extramedullary leukemic burden support the notion of the in utero, development of congenital leukemia.
引用
收藏
页码:148 / 152
页数:5
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