Prognostic factors in pulmonary arterial hypertension with Dana Point group 1

Aims: To clarify the prognosis and prognostic factors in pulmonary arterial hypertension (PAH) patients in real-world medical practice in the Tokai area in Japan. Main methods: We conducted a retrospective, multicenter observational study. The data of 8 I patients diagnosed with Dana Point group 1 or 1' PAH was collected from January 2005 to January 2013. The primary outcome was all-cause death. Key findings: The patients consisted of 34 cases of idiopathic PAH (IPAH), 28 of connective tissue-associated PAH (CTD-PAH), 16 of congenital heart disease-associated PAH (CHD-PAH) and others. Mean age was 51 years and mean observation period was 46 months. The systolic blood pressure (BPs) was 117 +/- 23 mm Hg. Pericardial effusion was observed in 27.0% of patients. The mean right atrial pressure (mRAP) was 102 +/- 7.3 mm Hg. In the univariate Cox regression analysis, WHO-FCS III & IV, a cardiac index (CI) <2.5 L/min/m(2), and the presence of pericardial effusion at baseline were significantly associated with all-cause death. In the multivariate analysis, the pericardial effusion (HR 3.3, 95% CI 1.03-10.63, p = 0.04) and mRAP (HR 3.2, 95% CI 1.03-9.83, p = 0.04) or CI < 2.5 L/min/m(2) (HR 3.89,95% CI 1.05-14.45, p = 0.04) were the independent predictors of mortality. Significance: The presence of pericardial effusion and mRAP or CI < 2.5 L/min/m(2) at diagnosis indicated high mortality. (C) 2014 The Authors. Published by Elsevier Inc.