Resistance of CA1 Pyramidal Cells to STZ-Induced Diabetes in Young Rats

被引：0

作者：

Fazeli, Seyyed Amirhossein ^{[2
]}

Gharravi, Anneh Mohammad ^{[2
]}

Jahanshahi, Mehrdad ^{[3
]}

Ghafari, Soraya ^{[2
]}

Behnampour, Naser ^{[4
]}

Golalipour, Mohammad Jafar ^{[1
]}

机构：

[1] Gorgan Univ Med Sci, Dept Anat Sci Embryol & Histol, Gorgan, Iran

[2] Gorgan Univ Med Sci, Dept Histol & Embryol, Gorgan, Iran

[3] Gorgan Univ Med Sci, Dept Anat, Gorgan, Iran

[4] Gorgan Univ Med Sci, Dept Hlth, Gorgan, Iran

来源：

INTERNATIONAL JOURNAL OF MORPHOLOGY | 2009年 / 27卷 / 04期

关键词：

Pyramidal cell density; CA1; Hippocampus; Diabetes; Rat; HIPPOCAMPAL SYNAPTIC PLASTICITY; NERVOUS-SYSTEM COMPLICATIONS; C-PEPTIDE; INSULIN; LIGHT;

D O I：

暂无

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The pyramidal cell density of CA1 hippocampal subfield following STZ-induced diabetes in young rats were studied. 12 male albino 6-week Wistar rats were allocated equally in groups of normal and diabetic. Hyperglycemia induced by Streptozotocin (80 mg/kg) in animals of diabetic group. After 5 weeks of study, all the rats were sacrificed and coronal sections were taken from dorsal hippocampal formation of the right cerebral hemispheres and stained with crysel violet. The area densities of the CA1 pyramidal cells were measured and compared among two groups. No significant difference between the densities of two experimental groups was found. The results can arise from the short period of diabetes and also the possible regenerative processes in developing brain of the young diabetic rats which compensated significant diabetes-induced neuronal loss.

引用

页码：997 / 1001

页数：5

共 17 条

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