A Concise and Efficient Approach to 2,6-Disubstituted 4-Fluoropyrimidines from α-CF3 Aryl Ketones

被引：14

作者：

Liu, Fangran ^{[1
,2
]}

Zhang, Xiaofei ^{[2
]}

Qian, Qun ^{[1
]}

Yang, Chunhao ^{[2
]}

机构：

[1] Shanghai Univ, Dept Chem, 99 Shang Da Rd, Shanghai 200444, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2020年 / 52卷 / 02期

基金：

中国国家自然科学基金;

关键词：

fluoropyrimidine; alpha-CF3 aryl ketone; metal-free; mild conditions; PYRIMIDINE; INHIBITORS; FLUORINE; DESIGN; CHEMISTRY; DISCOVERY;

D O I：

10.1055/s-0039-1690248

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, a concise and efficient protocol to synthesize a series of 2,6-disubstituted 4-fluoropyrimidines as universal and useful building blocks in medicinal chemistry is reported. From readily accessible alpha-CF3 aryl ketones and different amidine hydrochlorides, this method provides a very practical approach to this kind of compounds under mild conditions with good to excellent yields.

引用

页码：273 / 280

页数：8

共 26 条

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