The impact of COVID-19 on patients with asthma

被引:162
作者
Izquierdo, Jose Luis [1 ,2 ]
Almonacid, Carlos [2 ,3 ]
Gonzalez, Yolanda [4 ]
Rio-Bermudez, Carlos Del [4 ]
Ancochea, Julio [5 ,6 ,7 ]
Cardenas, Remedios [8 ]
Lumbreras, Sara [4 ,9 ]
Soriano, Joan B. [5 ,6 ,7 ]
机构
[1] Univ Hosp Guadalajara, Resp Med, Guadalajara, Spain
[2] Univ Alcala, Dept Med & Med Specialties, Madrid, Spain
[3] Univ Hosp Ramon & Cajal, Resp Med, Madrid, Spain
[4] Savana Med, Madrid, Spain
[5] Hosp Univ La Princesa, Resp Med, Madrid, Spain
[6] Univ Autonoma Madrid, Madrid, Spain
[7] Inst Salud Carlos III ISCIII, Ctr Invest Red Enfermedades Resp CIBERES, Madrid, Spain
[8] Univ Hosp Guadalajara, Allergy, Guadalajara, Spain
[9] Univ Pontificia Comillas, Madrid, Spain
关键词
RESPIRATORY HEALTH; PREVALENCE; SARS-COV-2; GUIDELINES;
D O I
10.1183/13993003.03142-2020
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Background: An association between the severity of coronavirus disease 2019 (COVID-19) and the presence of certain chronic conditions has been suggested. However, unlike influenza and other viruses, the disease burden of COVID-19 in patients with asthma has been less evident. Objective: To understand the impact of COVID-19 in patients with asthma. Methods: Using big-data analytics and artificial intelligence through the SAVANA Manager clinical platform, we analysed clinical data from patients with asthma from January 1 to May 10, 2020. Results: Out of 71 182 patients with asthma, 1006 (1.41%) suffered from COVID-19. Compared to asthmatic individuals without COVID-19, patients with asthma and COVID-19 were significantly older (55 versus 42 years), predominantly female (66% versus 59%), smoked more frequently and had higher prevalence of hypertension, dyslipidaemias, diabetes and obesity. Allergy-related factors such as rhinitis and eczema were less common in asthmatic patients with COVID-19 (p<0.001). In addition, higher prevalence of these comorbidities was observed in patients with COVID-19 who required hospital admission. The use of inhaled corticosteroids (ICS) was lower in patients who required hospitalisation due to COVID-19, as compared to non-hospitalised patients (48.3% versus 61.5%; OR 0.58, 95% CI 0.44 0.77). Although patients treated with biologics (n=865; 1.21%) showed increased severity and more comorbidities at the ear, nose and throat level, COVID-19-related hospitalisations in these patients were relatively low (0.23%). Conclusion: Patients with asthma and COV1D-19 were older and at increased risk due to comorbidity-related factors. ICS and biologics are generally safe and may be associated with a protective effect against severe COVID-19 infection.
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页数:9
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