A facile synthesis of 3,4-disubstituted-1,2-dihydro-5H-pyrrol-2-ones

被引：0

作者：

Bhandari, K ^{[1
]}

Sharma, VL ^{[1
]}

机构：

[1] Cent Drug Res Inst, Div Chem Technol, Lucknow 226001, Uttar Pradesh, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2004年 / 43卷 / 11期

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D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and efficient method for the synthesis of 3,4-disubstituted-1,2-dihydro-5H-pyrrol-2-ones 8a,c-f is reported. The method involves the hydrogenation of cyanohydrins of 2-alkyl-3-oxobutyric acid alkyl esters 1a-f, over Raney Ni at 50 psi to furnish hitherto unknown aminoacetyl intermediates 6a-f in quantitative yields which are cyclised to the targeted compounds.

引用

页码：2467 / 2470

页数：4

共 10 条

[1] DIASTEREOSELECTIVE SYNTHESIS OF PHYCOCYANOBILIN CYSTEINE ADDUCTS [J].

BISHOP, JE ;

NAGY, JO ;

OCONNELL, JF ;

RAPOPORT, H .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (21) :8024-8035

[2]

Böhme R, 1999, SYNTHESIS-STUTTGART, P2096

[3] SYNTHESIS AND PROPERTIES OF A BILIRUBIN ANALOG WITH PROPIONIC-ACID GROUPS REPLACED BY CARBOXYL [J].

BYUN, YS ;

LIGHTNER, DA .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1991, 28 (07) :1683-1692

[4] SIMPLE PREPARATION OF A VERY ACTIVE RANEY NICKEL CATALYST [J].

DOMINGUEZ, X ;

LOPEZ, IC ;

FRANCO, R .

JOURNAL OF ORGANIC CHEMISTRY, 1961, 26 (05) :1625-&

[5]

ENGLERT H, 1999, Patent No. 5631275

[6]

GERLACH W, 1998, Patent No. 19647000

[7]

PLIENINGER H, 1964, LIEBIGS ANN CHEM, V680, P60

[8]

UMINO N, 1976, TETRAHEDRON LETT, V33, P2875

[9]

WEYER R, 1992, DRUGS FUTURE, V17, P794

[10]

WIELAND T, 1972, LIEBIGS ANN CHEM, V756, P14

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