A facile synthesis of 3,4-disubstituted-1,2-dihydro-5H-pyrrol-2-ones

被引：0
|
作者：
Bhandari, K [1 ]
Sharma, VL [1 ]
机构：
[1] Cent Drug Res Inst, Div Chem Technol, Lucknow 226001, Uttar Pradesh, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2004年 / 43卷 / 11期
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile and efficient method for the synthesis of 3,4-disubstituted-1,2-dihydro-5H-pyrrol-2-ones 8a,c-f is reported. The method involves the hydrogenation of cyanohydrins of 2-alkyl-3-oxobutyric acid alkyl esters 1a-f, over Raney Ni at 50 psi to furnish hitherto unknown aminoacetyl intermediates 6a-f in quantitative yields which are cyclised to the targeted compounds.
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页码：2467 / 2470
页数：4
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