Effect of oxygen plasma treatment on non-thrombogenicity of diamond-like carbon films

被引：26

作者：

Nagashima, S. ^{[2
]}

Hasebe, T. ^{[1
,2
]}

Kamijo, A. ^{[3
]}

Yoshimoto, Y. ^{[2
]}

Hotta, A. ^{[2
]}

Morita, H. ^{[1
]}

Terada, H. ^{[1
]}

Tanaka, M. ^{[4
]}

Takahashi, K. ^{[4
]}

Suzuki, T. ^{[2
]}

机构：

[1] Toho Univ, Sakura Med Ctr, Dept Radiol, Sakura Ku, Chiba 2858741, Japan

[2] Keio Univ, Grad Sch Sci & Technol, Ctr Sci Environm Resources & Energy, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

[3] Yokohama City Univ Med, Dept Transfus Med, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

[4] Tokyo Univ Hosp, Dept Transfus Med, Bunkyo Ku, Tokyo 1138655, Japan

来源：

关键词：

Diamond-like carbon; Plasma CVD; Surface characterization; Biomedical applications; ION IMPLANTATION-DEPOSITION; BLOOD COMPATIBILITY; AMORPHOUS-CARBON; BIOMEDICAL APPLICATIONS; PLATELET ACTIVATION; PROTEIN ADSORPTION; SURFACE-ENERGY; DLC COATINGS; HEMOCOMPATIBILITY; ADHESION;

D O I：

10.1016/j.diamond.2010.02.003

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The non-thrombogenicity of oxygen-plasma-treated DLC films was investigated as surface coatings for medical devices. DLC films were deposited on polycarbonate substrates by a radio frequency plasma enhanced chemical vapor deposition method using acetylene gas. The deposited DLC films were then treated with plasma of oxygen gas at powers of 15W, 50W, and 200W. Wettability was evaluated by water contact angle measurements and the changes in surface chemistry and roughness were examined by X-ray photoelectron spectroscopy and atomic force microscope analysis, respectively. Each oxygen-plasma-treated DLC film exhibited a hydrophilic nature with water contact angles of 11.1 degrees, 17.7 degrees and 36.8 degrees. The non-thrombogenicity of the samples was evaluated through the incubation with platelet-rich plasma isolated from human whole blood. Non-thrombogenic properties dramatically improved for both 15 W- and 50 W-oxygen-plasma-treated DLC films. These results demonstrate that the oxygen plasma treatment at lower powers promotes the non-thrombogenicity of DLC films with highly hydrophilic surfaces. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：861 / 865

页数：5

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