Effect of Halogen Atom Localization on the Level of Antimycobacterial Activity of 2-Amino-4-arylamino-6-methylpyrimidines

被引：2

作者：

Erkin, A. V. ^{[1
]}

Krutikov, V. I. ^{[1
]}

机构：

[1] St Petersburg State Inst Technol, St Petersburg 190013, Russia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2010年 / 80卷 / 04期

关键词：

Carbon Tetrachloride; Phosphorus Pentoxide; Antimycobacterial Activity; Phosphorus Oxychloride; Aminopyrimidine;

D O I：

10.1134/S1070363210040237

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several hydrochlorides of 2-alkyl(cycloalkyl, aralkyl)-5-bromo-6-methyl-4-phenylaminopyrimidines have been synthesized as isosteric analogs of the corresponding 2-alkyl(cycloalkyl, aralkyl)-4-(3-bromophenyl)amino-6-methylpyrimidine hydrochlorides. Moving the bromine atom from the benzene ring into the heterocycle is accompanied by a significant decrease in the level of antimycobacterial activity.

引用

页码：818 / 824

页数：7