Fifty Ways To Inhibit Motility via Cyclic Di-GMP: the Emerging Pseudomonas aeruginosa Swarming Story

被引：13

作者：

McCarter, Linda L. ^{[1
]}

Gomelsky, Mark ^{[2
]}

机构：

[1] Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA

[2] Univ Wyoming, Dept Mol Biol, Laramie, WY 82071 USA

来源：

JOURNAL OF BACTERIOLOGY | 2015年 / 197卷 / 03期

基金：

美国国家科学基金会;

关键词：

FLAGELLAR MOTOR; BIOFILM FORMATION; 2ND-MESSENGER; CHEMOTAXIS; STATORS; PHOSPHODIESTERASE; TRANSCRIPTION; COMPLEXES; CELLULOSE; BACTERIA;

D O I：

10.1128/JB.02483-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

There are numerous ways by which cyclic dimeric GMP (c-di-GMP) inhibits motility. Kuchma et al. (S. L. Kuchma, N. J. Delalez, L. M. Filkins, E. A. Snavely, J. P. Armitage, and G. A. O'Toole, J. Bacteriol. 197: 420-430, 2015, http://dx. doi. org/10.1128/JB. 02130-14) offer a new, previously unseen way of swarming motility inhibition in Pseudomonas aeruginosa PA14. This bacterium possesses a single flagellum with one rotor and two sets of stators, only one of which can provide torque for swarming. The researchers discovered that elevated levels of c-di-GMP inhibit swarming by skewing stator selection in favor of the nonfunctional, "bad" stators.

引用

页码：406 / 409

页数：4

共 45 条

[11] Sodium-dependent dynamic assembly of membrane complexes in sodium-driven flagellar motors
Fukuoka, Hajime
Wada, Tomoyuki
Kojima, Seiji
Ishijima, Akihiko
Homma, Michio
[J]. MOLECULAR MICROBIOLOGY, 2009, 71 (04) : 825 - 835
[12] Identification of FleQ from Pseudomonas aeruginosa as a c-di-GMP-responsive transcription factor
Hickman, Jason W.
Harwood, Caroline S.
[J]. MOLECULAR MICROBIOLOGY, 2008, 69 (02) : 376 - 389
[13] Properties of motility in Bacillus subtilis powered by the H+-coupled MotAB flagellar stator, Na+-coupled MotPS or hybrid stators MotAS or MotPB
Ito, M
Terahara, N
Fujinami, S
Krulwich, TA
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2005, 352 (02) : 396 - 408
[14] Cloning and characterization of chemotaxis genes in Pseudomonas aeruginosa
Kato, J
Nakamura, T
Kuroda, A
Ohtake, H
[J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1999, 63 (01) : 155 - 161
[15] EFFECTS OF MOT GENE-EXPRESSION ON THE STRUCTURE OF THE FLAGELLAR MOTOR
KHAN, S
DAPICE, M
REESE, TS
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1988, 202 (03) : 575 - 584
[16] Vibrio cholerae VpsT Regulates Matrix Production and Motility by Directly Sensing Cyclic di-GMP
Krasteva, Petya V.
Fong, Jiunn C. N.
Shikuma, Nicholas J.
Beyhan, Sinem
Navarro, Marcos V. A. S.
Yildiz, Fitnat H.
Sondermann, Holger
[J]. SCIENCE, 2010, 327 (5967) : 866 - 868
[17] Cyclic Di-GMP-Mediated Repression of Swarming Motility by Pseudomonas aeruginosa PA14 Requires the MotAB Stator
Kuchma, S. L.
Delalez, N. J.
Filkins, L. M.
Snavely, E. A.
Armitage, J. P.
O'Toole, G. A.
[J]. JOURNAL OF BACTERIOLOGY, 2015, 197 (03) : 420 - 430
[18] BifA, a cyclic-di-GMP phosphodiesterase, inversely regulates biofilm formation and swarming motility by Pseudomonas aeruginosa PA14
Kuchma, Sherry L.
Brothers, Kimberly M.
Merritt, Judith H.
Liberati, Nicole T.
Ausubel, Frederick M.
O'Toole, George A.
[J]. JOURNAL OF BACTERIOLOGY, 2007, 189 (22) : 8165 - 8178
[19] Stoichiometry and turnover in single, functioning membrane protein complexes
Leake, Mark C.
Chandler, Jennifer H.
Wadhams, George H.
Bai, Fan
Berry, Richard M.
Armitage, Judith P.
[J]. NATURE, 2006, 443 (7109) : 355 - 358
[20] Dynamics of mechanosensing in the bacterial flagellar motor
Lele, Pushkar P.
Hosu, Basarab G.
Berg, Howard C.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (29) : 11839 - 11844

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