Fifty Ways To Inhibit Motility via Cyclic Di-GMP: the Emerging Pseudomonas aeruginosa Swarming Story

被引：13

作者：

McCarter, Linda L. ^{[1
]}

Gomelsky, Mark ^{[2
]}

机构：

[1] Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA

[2] Univ Wyoming, Dept Mol Biol, Laramie, WY 82071 USA

来源：

JOURNAL OF BACTERIOLOGY | 2015年 / 197卷 / 03期

基金：

美国国家科学基金会;

关键词：

FLAGELLAR MOTOR; BIOFILM FORMATION; 2ND-MESSENGER; CHEMOTAXIS; STATORS; PHOSPHODIESTERASE; TRANSCRIPTION; COMPLEXES; CELLULOSE; BACTERIA;

D O I：

10.1128/JB.02483-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

There are numerous ways by which cyclic dimeric GMP (c-di-GMP) inhibits motility. Kuchma et al. (S. L. Kuchma, N. J. Delalez, L. M. Filkins, E. A. Snavely, J. P. Armitage, and G. A. O'Toole, J. Bacteriol. 197: 420-430, 2015, http://dx. doi. org/10.1128/JB. 02130-14) offer a new, previously unseen way of swarming motility inhibition in Pseudomonas aeruginosa PA14. This bacterium possesses a single flagellum with one rotor and two sets of stators, only one of which can provide torque for swarming. The researchers discovered that elevated levels of c-di-GMP inhibit swarming by skewing stator selection in favor of the nonfunctional, "bad" stators.

引用

页码：406 / 409

页数：4

共 45 条

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