Palladium catalysts have been widely adopted for organic synthesis and diverse industrial applications given their efficacy and safety, yet their biological in vivo use has been limited to date. Here we show that nanoencapsulated palladium is an effective means to target and treat disease through in vivo catalysis. Palladium nanoparticles (Pd-NPs) were created by screening different Pd compounds and then encapsulating bis[tri(2-furyl) phosphine] palladium(II) dichloride in a biocompatible poly(lactic-co-glycolic acid)-b-polyethyleneglycol platform. Using mouse models of cancer, the NPs efficiently accumulated in tumours, where the Pd-NP activated different model prodrugs. Longitudinal studies confirmed that prodrug activation by Pd-NP inhibits tumour growth, extends survival in tumour-bearing mice and mitigates toxicity compared to standard doxorubicin formulations. Thus, here we demonstrate safe and efficacious in vivo catalytic activity of a Pd compound in mammals.
机构:
Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, David H Koch Ctr Appl Res Genitourinary Canc, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, David H Koch Ctr Appl Res Genitourinary Canc, Houston, TX 77030 USA
Alexander, Stephanie
Weigelin, Bettina
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Radboud Univ Nijmegen, Med Ctr, Dept Cell Biol, NL-6525 ED Nijmegen, NetherlandsUniv Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, David H Koch Ctr Appl Res Genitourinary Canc, Houston, TX 77030 USA
Weigelin, Bettina
Winkler, Frank
论文数: 0引用数: 0
h-index: 0
机构:
Heidelberg Univ, Neurol Clin, Dept Neurooncol, Heidelberg, Germany
Heidelberg Univ, Natl Ctr Tumor Dis, Heidelberg, Germany
German Canc Res Ctr, Heidelberg, GermanyUniv Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, David H Koch Ctr Appl Res Genitourinary Canc, Houston, TX 77030 USA
Winkler, Frank
Friedl, Peter
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h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, David H Koch Ctr Appl Res Genitourinary Canc, Houston, TX 77030 USA
Radboud Univ Nijmegen, Med Ctr, Dept Cell Biol, NL-6525 ED Nijmegen, NetherlandsUniv Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, David H Koch Ctr Appl Res Genitourinary Canc, Houston, TX 77030 USA
机构:
MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USAMIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
Bertrand, Nicolas
Wu, Jun
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Lab Nanomed & Biomat,Dept Anesthesiol, Boston, MA 02115 USAMIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
Wu, Jun
Xu, Xiaoyang
论文数: 0引用数: 0
h-index: 0
机构:
MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
Harvard Univ, Sch Med, Brigham & Womens Hosp, Lab Nanomed & Biomat,Dept Anesthesiol, Boston, MA 02115 USAMIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
Xu, Xiaoyang
Kamaly, Nazila
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h-index: 0
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Harvard Univ, Sch Med, Brigham & Womens Hosp, Lab Nanomed & Biomat,Dept Anesthesiol, Boston, MA 02115 USAMIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
Kamaly, Nazila
Farokhzad, Omid C.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Lab Nanomed & Biomat,Dept Anesthesiol, Boston, MA 02115 USAMIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
机构:
Yeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USAYeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA
del Amo, David Soriano
Wang, Wei
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h-index: 0
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Yeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USAYeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA
Wang, Wei
Jiang, Hao
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h-index: 0
机构:
Yeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USAYeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA
Jiang, Hao
Besanceney, Christen
论文数: 0引用数: 0
h-index: 0
机构:
Yeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USAYeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA
Besanceney, Christen
Yan, Amy C.
论文数: 0引用数: 0
h-index: 0
机构:
Yeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USAYeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA
Yan, Amy C.
Levy, Matthew
论文数: 0引用数: 0
h-index: 0
机构:
Yeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USAYeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA
Levy, Matthew
Liu, Yi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Lawrence Berkeley Lab, Mol Foundry, Berkeley, CA 94720 USAYeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA
Liu, Yi
Marlow, Florence L.
论文数: 0引用数: 0
h-index: 0
机构:Yeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA
Marlow, Florence L.
Wu, Peng
论文数: 0引用数: 0
h-index: 0
机构:
Yeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USAYeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA
机构:
Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, David H Koch Ctr Appl Res Genitourinary Canc, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, David H Koch Ctr Appl Res Genitourinary Canc, Houston, TX 77030 USA
Alexander, Stephanie
Weigelin, Bettina
论文数: 0引用数: 0
h-index: 0
机构:
Radboud Univ Nijmegen, Med Ctr, Dept Cell Biol, NL-6525 ED Nijmegen, NetherlandsUniv Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, David H Koch Ctr Appl Res Genitourinary Canc, Houston, TX 77030 USA
Weigelin, Bettina
Winkler, Frank
论文数: 0引用数: 0
h-index: 0
机构:
Heidelberg Univ, Neurol Clin, Dept Neurooncol, Heidelberg, Germany
Heidelberg Univ, Natl Ctr Tumor Dis, Heidelberg, Germany
German Canc Res Ctr, Heidelberg, GermanyUniv Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, David H Koch Ctr Appl Res Genitourinary Canc, Houston, TX 77030 USA
Winkler, Frank
Friedl, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, David H Koch Ctr Appl Res Genitourinary Canc, Houston, TX 77030 USA
Radboud Univ Nijmegen, Med Ctr, Dept Cell Biol, NL-6525 ED Nijmegen, NetherlandsUniv Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, David H Koch Ctr Appl Res Genitourinary Canc, Houston, TX 77030 USA
机构:
MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USAMIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
Bertrand, Nicolas
Wu, Jun
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Lab Nanomed & Biomat,Dept Anesthesiol, Boston, MA 02115 USAMIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
Wu, Jun
Xu, Xiaoyang
论文数: 0引用数: 0
h-index: 0
机构:
MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
Harvard Univ, Sch Med, Brigham & Womens Hosp, Lab Nanomed & Biomat,Dept Anesthesiol, Boston, MA 02115 USAMIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
Xu, Xiaoyang
Kamaly, Nazila
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Lab Nanomed & Biomat,Dept Anesthesiol, Boston, MA 02115 USAMIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
Kamaly, Nazila
Farokhzad, Omid C.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Lab Nanomed & Biomat,Dept Anesthesiol, Boston, MA 02115 USAMIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
机构:
Yeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USAYeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA
del Amo, David Soriano
Wang, Wei
论文数: 0引用数: 0
h-index: 0
机构:
Yeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USAYeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA
Wang, Wei
Jiang, Hao
论文数: 0引用数: 0
h-index: 0
机构:
Yeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USAYeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA
Jiang, Hao
Besanceney, Christen
论文数: 0引用数: 0
h-index: 0
机构:
Yeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USAYeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA
Besanceney, Christen
Yan, Amy C.
论文数: 0引用数: 0
h-index: 0
机构:
Yeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USAYeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA
Yan, Amy C.
Levy, Matthew
论文数: 0引用数: 0
h-index: 0
机构:
Yeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USAYeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA
Levy, Matthew
Liu, Yi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Lawrence Berkeley Lab, Mol Foundry, Berkeley, CA 94720 USAYeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA
Liu, Yi
Marlow, Florence L.
论文数: 0引用数: 0
h-index: 0
机构:Yeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA
Marlow, Florence L.
Wu, Peng
论文数: 0引用数: 0
h-index: 0
机构:
Yeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USAYeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA