Synthesis and self-assembly of amphiphilic precision glycomacromolecules

被引：4

作者：

Banger, Alexander ^{[1
]}

Sindram, Julian ^{[2
]}

Otten, Marius ^{[2
]}

Kania, Jessica ^{[1
]}

Wilms, Dimitri ^{[1
]}

Strzelczyk, Alexander ^{[1
]}

Miletic, Sean ^{[3
,4
,5
]}

Marlovits, Thomas C. ^{[3
,4
,5
]}

Karg, Matthias ^{[2
]}

Hartmann, Laura ^{[1
]}

机构：

[1] Heinrich Heine Univ, Inst Organ & Macromol Chem, Univ Str 1, D-40225 Dusseldorf, Germany

[2] Heinrich Heine Univ, Inst Phys Chem Colloids & Nanoopt 1, Univ Str 1, D-40225 Dusseldorf, Germany

[3] Univ Med Ctr Hamburg Eppendorf UKE, Inst Struct & Syst Biol, Hamburg, Germany

[4] Ctr Struct Syst Biol CSSB, Hamburg, Germany

[5] Deutsch Elektronen Synchrotron Zentrum DESY, Hamburg, Germany

来源：

POLYMER CHEMISTRY | 2021年 / 12卷 / 33期

关键词：

NILE RED; SURFACTANT; MICELLES; NANOSTRUCTURES; POLYMERIZATION; GLYCOPOLYMERS; COOPERATIVITY; FLUORESCENCE; ABSORPTION; VESICLES;

D O I：

10.1039/d1py00422k

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

We present the synthesis of so called amphiphilic glycomacromolecules (APGs) by using solid-phase polymer synthesis. Based on tailor made building blocks, monodisperse APGs with varying compositions are synthesized, introducing carbohydrate side chains and crosslinkable units at defined positions within the macromolecule. Self-assembly of the APGs is characterized via spectroscopic as well as scattering techniques and reveals structural dependencies between APG composition and self-assembly behavior such as the formation of spherical vs. worm-like micelles. Furthermore, polymerizable units within the APGs allow for fixation of the self-assembled structures. Carbohydrate presenting micelles are then evaluated as inhibitors of bacterial adhesion demonstrating their potential for biomedical applications.

引用

页码：4795 / 4802

页数：8

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