Resident mesenchymal progenitors of articular cartilage

被引：52

作者：

Candela, Maria Elena ^{[1
]}

Yasuhara, Rika ^{[2
]}

Iwamoto, Masahiro ^{[1
,3
]}

Enomoto-Iwamoto, Motomi ^{[1
,3
]}

机构：

[1] Childrens Hosp Philadelphia, Dept Surg, Div Orthopaed Surg, Translat Res Program Pediat Orthopaed, Philadelphia, PA 19104 USA

[2] Showa Univ, Sch Dent, Dept Diagnost Sci, Div Pathol, Tokyo 142, Japan

[3] Univ Penn, Perleman Sch Med, McKay Orthopaed Res Lab, Philadelphia, PA 19104 USA

来源：

MATRIX BIOLOGY | 2014年 / 39卷

基金：

日本学术振兴会;

关键词：

Progenitors; Chondroprogenitors; Articular cartilage; Injury; Repair; GROWTH-FACTOR RECEPTOR; CHROMATIN PROTEIN HMGB2; STEM-CELL NICHE; SPATIAL-ORGANIZATION; EARLY OSTEOARTHRITIS; LIMB SKELETOGENESIS; BONE-DEVELOPMENT; SYNOVIAL JOINT; STROMAL CELLS; IN-VITRO;

D O I：

10.1016/j.matbio.2014.08.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Articular cartilage has poor capacity of self-renewal and repair. Insufficient number and activity of resident mesenchymal (connective tissue) progenitors is likely one of the underlying reasons. Chondroprogenitors reside not only in the superficial zone of articular cartilage but also in other zones of articular cartilage and in the neighboring tissues, including perichondrium (groove of Ranvier), synovium and fat pad. These cells may respond to injury and contribute to articular cartilage healing. In addition, marrow stromal cells can migrate through subchondral bone when articular cartilage is damaged. We should develop drugs and methods that correctly stimulate resident progenitors for improvement of repair and inhibition of degenerative changes in articular cartilage. (C) 2014 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

引用

页码：44 / 49

页数：6

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