Olfactory receptor gene family evolution in stickleback and medaka fishes

被引：6

作者：

Chen Ming ^{[1
,2
]}

Peng ZuoGang ^{[1
]}

He ShunPing ^{[1
]}

机构：

[1] Chinese Acad Sci, Lab Fish Phylogenet & Biogeog, Inst Hydrobiol, Wuhan 430072, Peoples R China

[2] Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China

来源：

SCIENCE CHINA-LIFE SCIENCES | 2010年 / 53卷 / 02期

基金：

中国国家自然科学基金;

关键词：

olfactory receptor; positive selection; binding site; CODON-SUBSTITUTION MODELS; NUCLEOTIDE SUBSTITUTION; ODORANT RECEPTORS; MOLECULAR-BASIS; MOUSE; SELECTION; PREDICTION; DYNAMICS; ORIGIN; CANINE;

D O I：

10.1007/s11427-010-0025-4

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Interaction of olfactory receptor (OR) genes with environmental odors is regarded as the first step of olfaction. In this study, OR genes of two fish, medaka (Oryzias latipes) and stickleback (Gasterosteus aculeatus), were identified and an evolutional analysis was conducted. The selection pressure of different TM regions and complete coding region were compared. Three TM regions (TM4, TM5 and TM6) were found to have higher average Ka/Ks values, which might be partly caused by positive selection as suggested by subsequent positive selection analysis. Further analysis showed that many PTSs overlap, or are adjacent to previously deduced binding sites in mammals. These results support the hypothesis that binding sites of fish OR genes may evolved under positive selection.

引用

页码：257 / 266

页数：10

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