Radiological characteristics based on isocitrate dehydrogenase mutations and 1p/19q codeletion in grade II and III gliomas

被引：26

作者：

Yamauchi, Takahiro ^{[1
,4
]}

Ohno, Makoto ^{[1
]}

Matsushita, Yuko ^{[1
,3
]}

Takahashi, Masamichi ^{[1
]}

Miyakita, Yasuji ^{[1
]}

Kitagawa, Yosuke ^{[1
]}

Kondo, Erika ^{[1
]}

Tsushita, Natsuko ^{[1
]}

Satomi, Kaishi ^{[2
]}

Yoshida, Akihiko ^{[2
]}

Ichimura, Koichi ^{[3
]}

Narita, Yoshitaka ^{[1
]}

机构：

[1] Natl Canc Ctr, Dept Neurosurg & Neurooncol, Chuo Ku, 5-1-1 Tsukiji, Tokyo 1040045, Japan

[2] Natl Canc Ctr, Dept Pathol & Clin Labs, Chuo Ku, Tokyo, Japan

[3] Natl Canc Ctr, Div Brain Tumor Translat Res, Res Inst, Chuo Ku, Tokyo, Japan

[4] Univ Fukui, Fac Med Sci, Dept Neurosurg, Div Med, Eiheiji, Fukui, Japan

来源：

BRAIN TUMOR PATHOLOGY | 2018年 / 35卷 / 03期

关键词：

Lower-grade glioma; Radiological features; Isocitrate dehydrogenase mutations; 1p/19q codeletion; CONTRAST ENHANCEMENT; OLIGODENDROGLIAL TUMORS; PROGNOSTIC-SIGNIFICANCE; ANAPLASTIC GLIOMAS; IDH; HETEROZYGOSITY; CLASSIFICATION; GLIOBLASTOMAS; EXPRESSION; SUBGROUPS;

D O I：

10.1007/s10014-018-0321-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The radiological features of lower-grade gliomas (LGGs) classified according to isocitrate dehydrogenase (IDH) mutations and codeletion of chromosomal arms 1p and 19q (1p/19q codeletion) remain unclear. We aimed to systematically characterize the radiological features of molecularly classified LGGs using IDH and 1p/19q codeletion statuses. One hundred and one LGGs were re-classified into 36 tumors with IDH mutations (IDH-Mut), 35 tumors with IDH-Mut and 1p/19q codeletion (IDH-Mut/Codel), and 30 tumors with wildtype IDH (IDH-Wt). Calcification, heterogeneous signal intensity in T2-weighted images, and cortical invasion were significantly more frequent in IDH-Mut/Codel than in IDH-Mut and IDH-Wt tumors (calcification: 48.6 vs 5.6 and 6.7%, heterogeneity: 94.3 vs 33.3 and 50%, and cortical invasion: 94.3 vs 55.6 and 40.0%, respectively). A frontal location was significantly more frequent for IDH-Mut and IDH-Mut/Codel than for IDH-Wt tumors (52.8 and 71.4 vs 12.1%, respectively), and dense contrast-enhancement was significantly more frequent in IDH-Wt than in IDH-Mut and IDH-Mut/Codel tumors (50.0 vs 2.8 and 2.9%, respectively). In conclusion, IDH-Mut/Codel tumors were characterized by calcification, frontal location, heterogeneous signal intensity, and cortical invasion; IDH-Mut tumors differed from IDH-Wt tumors according to predominant frontal lobe location and less frequent dense enhancement patterns.

引用

页码：148 / 158

页数：11

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