Kinetics of Epstein-Barr Virus (EBV) Neutralizing and Virus-Specific Antibodies after Primary Infection with EBV

被引：32

作者：

Bu, Wei ^{[1
]}

Hayes, Gregory M. ^{[2
]}

Liu, Hui ^{[2
]}

Gemmell, Lorraine ^{[2
]}

Schmeling, David O. ^{[3
]}

Radecki, Pierce ^{[1
]}

Aguilar, Fiona ^{[1
]}

Burbelo, Peter D. ^{[4
]}

Woo, Jennifer ^{[2
]}

Balfour, Henry H., Jr. ^{[3
,5
]}

Cohen, Jeffrey I. ^{[1
]}

机构：

[1] NIAID, Med Virol Sect, Infect Dis Lab, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[2] Medimmune, Mountain View, CA USA

[3] Univ Minnesota, Sch Med, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA

[4] Natl Inst Dent & Craniofacial Res, Dent Clin Res, NIH, Bethesda, MD USA

[5] Univ Minnesota, Sch Med, Dept Pathol, Minneapolis, MN 55455 USA

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2016年 / 23卷 / 04期

关键词：

NUCLEAR ANTIGEN 1; T-CELL RESPONSES; MONONUCLEOSIS; VACCINE; GP350; IMMUNOGENICITY; IDENTIFICATION; EXPRESSION; SEVERITY; EVALUATE;

D O I：

10.1128/CVI.00674-15

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Prospective studies of antibodies to multiple Epstein-Barr virus (EBV) proteins and EBV neutralizing antibodies in the same individuals before, during, and after primary EBV infection have not been reported. We studied antibody responses to EBV in college students who acquired primary EBV infection during prospective surveillance and correlated the kinetics of antibody response with the severity of disease. Neutralizing antibodies and enzyme-linked immunosorbent assay (ELISA) antibodies to gp350, the major target of neutralizing antibody, reached peak levels at medians of 179 and 333 days after the onset of symptoms of infectious mononucleosis, respectively. No clear correlation was found between the severity of the symptoms of infectious mononucleosis and the peak levels of antibody to individual viral proteins or to neutralizing antibody. In summary, we found that titers of neutralizing antibody and antibodies to multiple EBV proteins increase over many months after primary infection with EBV.

引用

页码：363 / 369

页数：7

共 29 条

[1] Behavioral, Virologic, and Immunologic Factors Associated With Acquisition and Severity of Primary Epstein-Barr Virus Infection in University Students [J].

Balfour, Henry H., Jr. ;

Odumade, Oludare A. ;

Schmeling, David O. ;

Mullan, Beth D. ;

Ed, Julie A. ;

Knight, Jennifer A. ;

Vezina, Heather E. ;

Thomas, William ;

Hogquist, Kristin A. .

JOURNAL OF INFECTIOUS DISEASES, 2013, 207 (01) :80-88

[2] A prospective clinical study of Epstein-Barr virus and host interactions during acute infectious mononucleosis [J].

Balfour, HH ;

Holman, CJ ;

Hokanson, KM ;

Lelonek, MM ;

Giesbrecht, JE ;

White, DR ;

Schmeling, DO ;

Webb, CH ;

Cavert, W ;

Wang, DH ;

Brundage, RC .

JOURNAL OF INFECTIOUS DISEASES, 2005, 192 (09) :1505-1512

[3] LIPS arrays for simultaneous detection of antibodies against partial and whole proteomes of HCV, HIV and EBV [J].

Burbelo, Peter D. ;

Bren, Kathleen E. ;

Ching, Kathryn H. ;

Gogineni, Emile S. ;

Kottilil, Shyam ;

Cohen, Jeffrey I. ;

Kovacs, Joseph A. ;

Iadarola, Michael J. .

MOLECULAR BIOSYSTEMS, 2011, 7 (05) :1453-1462

[4] Prolonged illness after infectious mononucleosis is associated with altered immunity but not with increased viral load [J].

Cameron, B ;

Bharadwaj, M ;

Burrows, J ;

Fazou, C ;

Wakefield, D ;

Hickie, I ;

Ffrench, R ;

Khanna, R ;

Lloyd, A .

JOURNAL OF INFECTIOUS DISEASES, 2006, 193 (05) :664-671

[5] Primary Immunodeficiencies Associated with EBV Disease [J].

Cohen, Jeffrey I. .

EPSTEIN BARR VIRUS, VOL 1: ONE HERPES VIRUS: MANY DISEASES, 2015, 390 :241-265

[6] Epstein-Barr virus infection. [J].

Cohen, JI .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (07) :481-492

[7]

GOLDSTEIN K, 1980, INFECT IMMUN, V29, P945

[8] Patients with Epstein Barr virus-positive lymphomas have decreased CD4+ T-cell responses to the viral nuclear antigen 1 [J].

Heller, Kevin N. ;

Arrey, Frida ;

Steinherz, Peter ;

Portlock, Carol ;

Chadburn, Amy ;

Kelly, Kara ;

Munz, Christian .

INTERNATIONAL JOURNAL OF CANCER, 2008, 123 (12) :2824-2831

[9] RELATION OF BURKITTS TUMOR-ASSOCIATED HERPES-TYPE VIRUS TO INFECTIOUS MONONUCLEOSIS [J].

HENLE, G ;

HENLE, W ;

DIEHL, V .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1968, 59 (01) :94-&

[10] ANTIBODY-RESPONSES TO EPSTEIN-BARR VIRUS-DETERMINED NUCLEAR ANTIGEN (EBNA)-1 AND EBNA-2 IN ACUTE AND CHRONIC EPSTEIN-BARR VIRUS-INFECTION [J].

HENLE, W ;

HENLE, G ;

ANDERSSON, J ;

ERNBERG, I ;

KLEIN, G ;

HORWITZ, CA ;

MARKLUND, G ;

RYMO, L ;

WELLINDER, C ;

STRAUS, SE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (02) :570-574

← 1 2 3 →