DDX53 Regulates Cancer Stem Cell-Like Properties by Binding to SOX-2

被引：22
作者：
Kim, Youngmi [1 ]
Yeon, Minjeong [1 ]
Jeoung, Dooil [1 ]
机构：
[1] Kangwon Natl Univ, Dept Biochem, Chunchon 24341, South Korea
来源：
MOLECULES AND CELLS | 2017年 / 40卷 / 05期
基金：
新加坡国家研究基金会;
关键词：
anti-cancer drug-resistance; cancer stem cell-like properties; DDX53; SOX-2; CANCER/TESTIS ANTIGEN CAGE; ANTICANCER DRUGS; FEEDBACK LOOP; SIDE POPULATION; CARCINOMA-CELLS; BLADDER-CANCER; GENE CAGE; EXPRESSION; INVASION; HDAC3;
D O I：
10.14348/molcells.2017.0001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This study investigated the role of cancer/testis antigen DDX53 in regulating cancer stem cell-like properties. DDX53 shows co-expression with CD133, a marker for cancer stem cells. DDX53 directly regulates the SOX-2 expression in anticancer drug-resistant Malme3M(R) cells. DDX53 and miR-200b were found to be involved in the regulation of tumor spheroid forming potential of Malme3M and Malme3M(R) cells. Furthermore, the self-renewal activity and the tumorigenic potential of Malme3M(R)-CD133 (+) cells were also regulated by DDX53. A miR-200b inhibitor induced the direct regulation of SOX-2 by DDX53 We therefore, conclude that DDX53 may serve as an immunotherapeutic target for regulating cancer stem-like properties of melanomas.
引用
收藏
页码：322 / 330
页数：9
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