Effect of green tea extract on the carbofuran induced toxicity in wistar rats

The present study is aimed to assess the effect of an extract of green tea on carbofuran induced toxicity in Wistar rats. Wistar rats were treated with carbofuran (5 mg/kg b.wt orally) for 30 days in the presence and absence of different concentrations of green tea extract. Administration of green tea extract was found to significantly reduce carbofuran induced toxicity in Wistar rats. Administration of green tea extract restored acetylcholinesterase (AChE) as well as other serum and tissue marker enzymes such as, lactate dehydrogenase (LDH), creatine kinase (CK) and gamma glutamyl transferase (gamma-GT), mitochondrial and carbohydrate metabolizing enzymes, which were altered by carbofuran. Decreased levels of antioxidant enzymes and GSH during carbofuran administration were increased by the green tea administration. Similarly, green tea extract administration reduced oxidative stress markers which were increased during carbofuran administration. Moreover, altered neurobehavioral problems produced by carbofuran were reversed by the green tea administration. Biochemical alterations were accompanied by histopathological changes resulted from carbofuran toxicity which were ameliorated following green tea administration. These studies concluded that green tea administration effectively protected the rats from carbofuran toxicity.