Comparative Study of the Synthetic Approaches and Biological Activities of the Bioisosteres of 1,3,4-Oxadiazoles and 1,3,4-Thiadiazoles over the Past Decade

被引：27

作者：

El-Masry, Rana M. ^{[1
]}

Kadry, Hanan H. ^{[2
]}

Taher, Azza T. ^{[2
,3
]}

Abou-Seri, Sahar M. ^{[4
]}

机构：

[1] October Univ Modern Sci & Arts MSA, Dept Organ Chem, Fac Pharm, 6th Of October City 12451, Egypt

[2] Cairo Univ, Dept Organ Pharmaceut Chem, Fac Pharm, Cairo 11562, Egypt

[3] October 6 Univ O6U, Dept Organ Pharmaceut Chem, Fac Pharm, 6th Of October City 12585, Egypt

[4] Cairo Univ, Dept Pharmaceut Chem, Fac Pharm, Cairo 11562, Egypt

来源：

MOLECULES | 2022年 / 27卷 / 09期

关键词：

1; 3; 4-oxadiazole; 4-thiadiazole; bioisosteres; synthesis; biological activity; structure-activity relationship; REAGENT-BASED CYCLIZATION; ANTIINFLAMMATORY ACTIVITY; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ELECTRONIC-STRUCTURE; ANTIOXIDANT ACTIVITY; ANTICANCER ACTIVITY; SCHIFF-BASE; DERIVATIVES; THIADIAZOLE;

D O I：

10.3390/molecules27092709

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The bioisosteres of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles are well-known pharmacophores for many medicinally important drugs. Throughout the past 10 years, 1,3,4-oxa-/thiadiazole nuclei have been very attractive to researchers for drug design, synthesis, and the study of their potential activity towards a variety of diseases, including microbial and viral infections, cancer, diabetes, pain, and inflammation. This work is an up-to-date comparative study that identifies the differences between 1,3,4-thiadiazoles and 1,3,4-oxadiazoles concerning their methods of synthesis from different classes of starting compounds under various reaction conditions, as well as their biological activities and structure-activity relationship.

引用

页数：56

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