Delivering optimal renal replacement therapy to critically ill patients with acute kidney injury

被引：35

作者：

Wald, Ron ^{[1
,2
,3
]}

Beaubien-Souligny, William ^{[4
]}

Chanchlani, Rahul ^{[5
]}

Clark, Edward G. ^{[6
]}

Neyra, Javier A. ^{[7
]}

Ostermann, Marlies ^{[8
]}

Silver, Samuel A. ^{[9
]}

Vaara, Suvi ^{[10
,11
]}

Zarbock, Alexander ^{[12
]}

Bagshaw, Sean M. ^{[13
,14
]}

机构：

[1] St Michaels Hosp, Div Nephrol, 61 Queen St East 9-140, Toronto, ON M5C 2T2, Canada

[2] Univ Toronto, 61 Queen St East 9-140, Toronto, ON M5C 2T2, Canada

[3] St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada

[4] Ctr Hosp Univ Montreal, Div Nephrol, Montreal, PQ, Canada

[5] McMaster Univ, Dept Pediat, Div Pediat Nephrol, Hamilton, ON, Canada

[6] Univ Ottawa, Dept Med, Div Nephrol, Ottawa, ON, Canada

[7] Univ Alabama Birmingham, Div Nephrol, Birmingham, AL USA

[8] Guys & St Thomas Hosp, Dept Crit Care Med, London, England

[9] Queens Univ, Kingston Hlth Sci Ctr, Div Nephrol, Kingston, ON, Canada

[10] Univ Helsinki, Dept Anesthesiol Intens Care & Pain Med, Div Intens Care Med, Helsinki, Finland

[11] Helsinki Univ Hosp, Helsinki, Finland

[12] Dept Anesthesiol Intens Care & Pain Med, Munster, Germany

[13] Univ Alberta, Dept Crit Care Med, Edmonton, AB, Canada

[14] Alberta Hlth Serv, Edmonton, AB, Canada

来源：

INTENSIVE CARE MEDICINE | 2022年 / 48卷 / 10期

关键词：

Acute kidney injury; Renal replacement therapy; Intensive care unit; Clinical trials; PERITONEAL-DIALYSIS; INTERMITTENT HEMODIALYSIS; SEVERE HYPONATREMIA; OUTCOMES; MODALITY; FAILURE; HEMOFILTRATION; MANAGEMENT; MULTICENTER; STRATEGIES;

D O I：

10.1007/s00134-022-06851-6

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Critical illness is often complicated by acute kidney injury (AKI). In patients with severe AKI, renal replacement therapy (RRT) is deployed to address metabolic dysfunction and volume excess until kidney function recovers. This review is intended to provide a comprehensive update on key aspects of RRT prescription and delivery to critically ill patients. Recently completed trials have enhanced the evidence base regarding several RRT practices, most notably the timing of RRT initiation and anticoagulation for continuous therapies. Better evidence is still needed to clarify several aspects of care including optimal targets for ultrafiltration and effective strategies for RRT weaning and discontinuation.

引用

页码：1368 / 1381

页数：14

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