NEDD4-2 (NEDD4L): The ubiquitin ligase for multiple membrane proteins

被引：145
作者：
Goel, Pranay [1 ,2 ]
Manning, Jantina A. [1 ]
Kumar, Sharad [1 ,2 ]
机构：
[1] Univ S Australia, Ctr Canc Biol, Adelaide, SA 5001, Australia
[2] Univ Adelaide, Dept Med, Adelaide, SA 5005, Australia
来源：
GENE | 2015年 / 557卷 / 01期
基金：
英国医学研究理事会;
关键词：
Ubiquitin; Ubiquitin protein ligases; NEDD4; family; Epithelial sodium channel (ENaC); Voltage-gated sodium channels (Na(v)s); Hypertension; EPITHELIAL NA+ CHANNEL; GATED SODIUM-CHANNELS; TIGHT JUNCTION FORMATION; DOWN-REGULATION; SURFACE EXPRESSION; NEDD4-2-MEDIATED INHIBITION; POTASSIUM CHANNEL; GENETIC-VARIATION; ENAC REGULATION; HERG CHANNEL;
D O I：
10.1016/j.gene.2014.11.051
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
NEDD4-2 (also known as NEDD4L, neural precursor cell expressed developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family which is known to bind and regulate a number of membrane proteins to aid in their internalization and turnover. Several of the NEDD4-2 substrates include ion channels, such as the epithelial and voltage-gated sodium channels. Given the critical function of NEDD4-2 in regulating membrane proteins, this ligase is essential for the maintenance of cellular homeostasis. In this article we review the biology and function of this important ubiquitin-protein ligase and discuss its pathophysiological significance. (C) 2014 Elsevier B.V. All rights reserved.
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页码：1 / 10
页数：10
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