NEDD4-2 (NEDD4L): The ubiquitin ligase for multiple membrane proteins

被引：138

作者：

Goel, Pranay ^{[1
,2
]}

Manning, Jantina A. ^{[1
]}

Kumar, Sharad ^{[1
,2
]}

机构：

[1] Univ S Australia, Ctr Canc Biol, Adelaide, SA 5001, Australia

[2] Univ Adelaide, Dept Med, Adelaide, SA 5005, Australia

来源：

GENE | 2015年 / 557卷 / 01期

基金：

英国医学研究理事会;

关键词：

Ubiquitin; Ubiquitin protein ligases; NEDD4; family; Epithelial sodium channel (ENaC); Voltage-gated sodium channels (Na(v)s); Hypertension; EPITHELIAL NA+ CHANNEL; GATED SODIUM-CHANNELS; TIGHT JUNCTION FORMATION; DOWN-REGULATION; SURFACE EXPRESSION; NEDD4-2-MEDIATED INHIBITION; POTASSIUM CHANNEL; GENETIC-VARIATION; ENAC REGULATION; HERG CHANNEL;

D O I：

10.1016/j.gene.2014.11.051

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

NEDD4-2 (also known as NEDD4L, neural precursor cell expressed developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family which is known to bind and regulate a number of membrane proteins to aid in their internalization and turnover. Several of the NEDD4-2 substrates include ion channels, such as the epithelial and voltage-gated sodium channels. Given the critical function of NEDD4-2 in regulating membrane proteins, this ligase is essential for the maintenance of cellular homeostasis. In this article we review the biology and function of this important ubiquitin-protein ligase and discuss its pathophysiological significance. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：1 / 10

页数：10

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