Eosinophilic esophagitis phenotypes: Ready for prime time?

被引：40

作者：

Atkins, Dan ^{[1
,2
,3
]}

Furuta, Glenn T. ^{[1
,3
,4
]}

Liacouras, Chris A. ^{[5
,6
]}

Spergel, Jonathan M. ^{[6
,7
]}

机构：

[1] Childrens Hosp Colorado, Gastrointestinal Eosinophil Dis Program, Aurora, CO USA

[2] Childrens Hosp Colorado, Sect Allergy Immunol, Aurora, CO USA

[3] Univ Colorado, Sch Med, Aurora, CO USA

[4] Childrens Hosp Colorado, Digest Hlth Inst, Sect Pediat Gastroenterol Hepatol & Nutr, Aurora, CO USA

[5] Childrens Hosp Philadelphia, Div Gastroenterol Hepatol & Nutr, Philadelphia, PA 19104 USA

[6] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA

[7] Childrens Hosp Philadelphia, Div Allergy & Immunol, Philadelphia, PA 19104 USA

来源：

PEDIATRIC ALLERGY AND IMMUNOLOGY | 2017年 / 28卷 / 04期

关键词：

eosinophilic esophagitis; phenotypes; symptom; treatment; PLACEBO-CONTROLLED TRIAL; ORAL VISCOUS BUDESONIDE; GASTROINTESTINAL DISORDERS; ASTHMA PHENOTYPES; CHILDHOOD ASTHMA; RANDOMIZED-TRIAL; FOOD ALLERGY; ANTI-IGE; CHILDREN; FLUTICASONE;

D O I：

10.1111/pai.12715

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Eosinophilic esophagitis (EoE) is one of the most common causes of reflux-like symptoms and feeding problems in children and food impaction and dysphagia in adults with a prevalence of 1: 2500. Therapeutic options include diet, use of swallowed corticosteroids, or dilation. In the last several years, recent clinical and translational researches have identified some common and distinctive features, for example, the varying response to diet and medications. As EoE shares some characteristics with both asthma and inflammatory bowel disease, the advances in these fields suggest that various phenotypes may also exist in patients with EoE. Here, we provide a rationale for EoE phenotypes and provide some suggestions for potential phenotypes based on histology, molecular signature, response to therapy or dietary therapy.

引用

收藏

页码：312 / 319

页数：8

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