A Facile and Efficient Synthesis of Oxindole Scaffolds through Linear Regioselective Reductive Coupling between Vinyl Sulfones and Isatins/Isatinimines

被引：1

作者：

Ramakrishna, K. ^{[1
]}

Arupula, Sanjeeva K. ^{[1
]}

Gudimella, Santosh K. ^{[1
]}

Raju, V. ^{[2
]}

Nanubollu, Jagadeesh B. ^{[3
]}

Meshram, Harshadas M. ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Med Chem & Pharmacol Div, Hyderabad 500007, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Fluroorgan Div, Hyderabad 500007, Andhra Pradesh, India

[3] Indian Inst Chem Technol, Lab Xray Crystallog, Hyderabad 500007, Andhra Pradesh, India

来源：

CHEMISTRYSELECT | 2017年 / 2卷 / 18期

关键词：

Atom economical; Linear regioselective reductive coupling; Mannich coupling; Oxindoles; Vinyl sulfones; HIGHLY ENANTIOSELECTIVE SYNTHESIS; CATALYZED ASYMMETRIC ADDITION; ARYLBORONIC ACIDS; ACTIVATED ALKENES; MANNICH REACTION; ALDOL REACTION; DERIVATIVES; ISATINS; (R)-CONVOLUTAMYDINE; 3-AMINOOXINDOLES;

D O I：

10.1002/slct.201700738

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Zn/CeCl3.7H(2)O mediated facile and an efficient synthesis of oxindoles motifs via linear regioselective reductive coupling between isatin/isatinimine derivatives and vinyl sulfones at room temperature has been described. This synthetic protocol is base free and allow for the synthesis of wide variety of oxindole motifs in moderate to high yields. This is the first example of Mannich-type coupling between isatinimines and vinyl sulfones.

引用

页码：5105 / 5109

页数：5