Anthelmintic activity of selected ethno-medicinal plant extracts on parasitic stages of Haemonchus contortus

被引:31
作者
Kumarasingha, Rasika [1 ,2 ]
Preston, Sarah [3 ]
Yeo, Tiong-Chia [4 ]
Lim, Diana S. L. [4 ]
Tu, Chu-Lee [4 ]
Palombo, Enzo A. [5 ]
Shaw, Jillian M. [6 ]
Gasser, Robin B. [3 ]
Boag, Peter R. [1 ,2 ,3 ]
机构
[1] Monash Univ, Monash Biomed Discovery Inst, Dev & Stem Cells Program, Melbourne, Vic 3800, Australia
[2] Monash Univ, Dept Biochem & Mol Biol, Melbourne, Vic 3800, Australia
[3] Univ Melbourne, Fac Vet & Agr Sci, Parkville, Vic 3010, Australia
[4] SBC, KM 20 Jalan Borneo Hts,Locked Bag 3032, Kuching 93990, Sarawak, Malaysia
[5] Swinburne Univ Technol, Fac Sci Engn & Technol, Dept Chem & Biotechnol, Hawthorn, Vic 3122, Australia
[6] Swinburne Univ Technol, Fac Hlth Arts & Design, Dept Hlth & Med Sci, Hawthorn, Vic 3122, Australia
来源
PARASITES & VECTORS | 2016年 / 9卷
基金
英国医学研究理事会;
关键词
Medicinal plant extracts; Anthelmintic activity; Developmental assay; In vitro-assay; CAENORHABDITIS-ELEGANS; DRUG-RESISTANCE; NEMATODE; LIVESTOCK; MODEL; TRANSCRIPTOME; MONEPANTEL; PROSPECTS; EFFICACY; GENOME;
D O I
10.1186/s13071-016-1458-9
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Background: Parasitic roundworms (nematodes) cause substantial morbidity and mortality in livestock animals globally, and considerable productivity losses to farmers. The control of these nematodes has relied largely on the use of a limited number of anthelmintics. However, resistance to many of these these anthelmintics is now widespread, and, therefore, there is a need to find new drugs to ensure sustained and effective treatment and control into the future. Methods: Recently, we developed a screening assay to test natural, plant extracts with known inhibitory effects against the free-living worm Caenorhabditis elegans. Using this assay, we assessed here the effects of the extracts on motility and development of parasitic larval stages of Haemonchus contortus, one of the most important nematodes of small ruminants worldwide. Results: The study showed that two of five extracts from Picria fel-terrae Lour. have a significant inhibitory effect (at concentrations of 3-5 mg/ml) on the motility and development of H. contortus larvae. Although the two extracts originated from the same plant, they displayed different levels of inhibition on motility and development, which might relate to the presence of various active constituents in these extracts, or the same constituents at different concentrations in distinct parts of the plant. Conclusions: These results suggest that extracts from P. fel-terrae Lour. have promising anthelmintic activity and that more broadly, plant extracts are a potential rich source of anthelmintics to combat helminthic diseases.
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页数:7
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