Progressive Multifocal Leukoencephalopathy in Chronic Lymphocytic Leukemia: A Report of Three Cases and Review of the Literature

被引：43

作者：

D'Souza, Anita ^{[1
]}

Wilson, Jon ^{[2
]}

Mukherjee, Sudipto ^{[1
]}

Jaiyesimi, Ishmael ^{[3
]}

机构：

[1] William Beaumont Hosp, Dept Internal Med, Royal Oak, MI 48017 USA

[2] William Beaumont Hosp, Dept Pathol, Royal Oak, MI 48017 USA

[3] William Beaumont Hosp, Dept Oncol, Royal Oak, MI 48017 USA

来源：

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | 2010年 / 10卷 / 01期

关键词：

Alemtuzumab; Fludarabine; JC virus; Rituximab; BONE-MARROW-TRANSPLANTATION; STEM-CELL TRANSPLANTATION; HUMAN-IMMUNODEFICIENCY-VIRUS; JC VIRUS; INFECTIOUS COMPLICATIONS; HUMAN POLYOMAVIRUS; ALPHA-INTERFERON; FLUDARABINE; PATIENT; PML;

D O I：

10.3816/CLML.2010.n.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the John Cunningham (JC) virus, a DNA papovavirus. It is usually associated with conditions causing profound immunodeficiency, classically seen in patients with HIV/AIDS. Since its first description in 1958, PML has also been associated with various lymphoproliferative malignancies, including chronic lymphocytic leukemia (CLL). With the use of newer chemotherapeutic agents such as the purine analogue fludarabine and various monoclonal antibodies in the treatment of CLL, more cases of PML are being described. In this article, we describe 3 patients encountered in our clinical practice having CLL and PML infection. All three patients had received fludarabine and rituximab at some point during the course of their chemotherapy. We provide these cases with a review of the literature.

引用

页数：9

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