Coagulology, biochemical profile and muscle pathology in calves diagnosed with nutritional muscular dystrophy

被引:11
作者
Zarczynska, K. [1 ]
Baumgartner, W. [2 ]
Sobiech, P. [1 ]
机构
[1] Univ Warmia & Mazury, Fac Vet Med, Dept Internal Dis, Oczapowskiego 14, PL-10957 Olsztyn, Poland
[2] Univ Vet Med, Clin Ruminants, Dept Food Anim & Vet Publ Hlth, Vet Pl 1, A-1210 Vienna, Austria
来源
POLISH JOURNAL OF VETERINARY SCIENCES | 2017年 / 20卷 / 02期
关键词
calves; coagulation profile; histopathology; Nutritional Muscular Dystrophy; selenium; VITAMIN-E; ALPHA-TOCOPHEROL; SELENIUM; HOMOCYSTEINE; COAGULATION; DISEASE; BLOOD; LAMBS; HYPERHOMOCYSTEINEMIA; SUPPLEMENTATION;
D O I
10.1515/pjvs-2017-0047
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
The aim of this study was to explain the correlations between selenium deficiency, hemostatic and biochemical disorders, and the progression of pathological changes in calves diagnosed with nutritional muscular dystrophy (NMD). The study was performed on 20 calves with supplementation of 8 ml selenium and vitamin E preparation and 20 calves with symptoms of NMD. Blood was sampled from calves aged 5, 12 and 19 days. On day 19, samples of the biceps femoris muscle were collected from 6 animals in each group for histopathological analysis. The following blood parameters were determined: PLT, PT, TT, APTT, fibrinogen and D-dimer concentrations, antithrombin III activity, glucose, selenium and vitamin E concentrations, activity of CK, LDH and GSH-Px. Muscle sections were stained with H&E and HBFP. Platelet counts were significantly lower in calves with symptoms of NMD. No significant differences in coagulation parameters were observed between the groups. Sick calves were diagnosed with hyperglycemia and elevation of CK and LDH activity. Selenium and vitamin E concentrations in the blood serum were significantly lower in the experimental group together with significant drop in GSH-Px activity. Changes characteristic of Zenker's necrosis were observed in a muscle of the sick animals. To our best knowledge this is the first study in which the attempt was made to explain the relationship between selenium deficiency and changes in the coagulation system in ruminants.
引用
收藏
页码:387 / 394
页数:8
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